Table 3 Correlation between SSBP2 expression and clinicopathologic features in hepatocellular carcinoma
Clinicopathologic features | n | SSBP2 expression | P-value (chi-square test) | |
|---|---|---|---|---|
Negative (%) (n = 173) | Positive (%) (n = 16) | |||
Tumor size | 0.895 | |||
< 5 cm | 121 | 111 (91.7%) | 10 (8.3%) | |
≥ 5 cm | 68 | 62 (91.2%) | 6 (8.8%) | |
Focality | 0.027 | |||
Single | 156 | 146 (93.6%) | 10 (6.4%) | |
Multiple | 33 | 27 (81.8%) | 6 (18.2%) | |
Histologic grade | 0.003 | |||
Grade 1 & 2 | 77 | 76 (98.7%) | 1 (1.3%) | |
Grade 3 & 4 | 112 | 97 (86.6%) | 15 (13.4%) | |
Small vessel invasion | 0.001 | |||
Not identified | 109 | 106 (97.2%) | 3 (2.8%) | |
Present | 80 | 67 (83.8%) | 13 (16.2%) | |
Large vessel invasion | 0.267 | |||
Not identified | 169 | 156 (92.3%) | 13 (7.7%) | |
Present | 20 | 17 (85.0%) | 3 (15.0%) | |
Perineural invasion | 0.348 | |||
Not identified | 184 | 169 (91.8%) | 15 (8.2%) | |
Present | 5 | 4 (80.0%) | 1 (20.0%) | |
AJCC stage | 0.146 | |||
I & II | 164 | 152 (92.7%) | 12 (7.3%) | |
III & IV | 25 | 21 (84.0%) | 4 (16.0%) | |
Ki-67 index | ||||
Mean (%) | 189 | 3.93 (±9.80) | 20.63 (±21.44) | < 0.001* |