Fig. 1

SSBP2 expression in human liver tissues. Representative sections of immunohistochemical staining for SSBP2 in normal liver tissue (a) (original magnification × 400), adjacent non-neoplastic liver tissue (b) (original magnification × 400), and hepatocellular carcinoma (c, d) (original magnification × 400). Whereas the nuclei of normal bile duct epithelium and sinusoidal endothelium are positive, the hepatocytes of normal and adjacent non-neoplastic liver tissues are all negative for SSBP2, and a subset of hepatocellular carcinomas shows positive staining. Representative HCC sample showing negative (c) and positive (d) nuclear staining in tumor cells