Skip to main content
Fig. 6 | BMC Cancer

Fig. 6

From: Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer

Fig. 6

Cholesterol depletion from malignant ascites by methyl β cyclodextrin (MβCD) inhibits malignant ascites-induced chemoresistance against CDDP. a Western blot of ABCG2, MDR1 and LXRα/β in whole cell lysates 24 h after co-treatment with malignant ascites and MβCD (cholesterol depleting agent in solution). (B1 and B2) CDDP and PAC induced apoptotic cell death after co-treatment with malignant ascites and MβCD. Apoptotic cells determined by Annexin V/PI staining. (Black box indicate control without CDDP/PAC treatment). Significant differences are indicated as follows. *P < 0.05, **P < 0.01, ***P < 0.001 a, b, c, d, e, f indicates homogeneous subsets, using one-way ANOVA followed by Scheffe’s post hoc test

Back to article page