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Table 2 The association between gene polymorphism of XRCC1 (rs25487), TP53(rs1042522) and cervical cancer

From: Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study

Variable

Groups

Co-dominate model

Recessive model

 

P-value

OR

95%CI

P-value

OR

95%CI

 rs25487

Cases vs NC

G/A

0.00*

2.00

1.14–3.50

0.02*

2.54

1.15–5.59

A/A

 

3.43

1.50–7.85

   

Cases vs OC

G/A

0.03*

1.61

0.91–2.87

0.03*

2.40

1.06–5.46

A/A

 

3.00

1.26–7.10

   

NC vs OC

G/A

0.76

0.81

0.45–1.43

0.91

0.95

0.37–2.43

A/A

 

0.87

0.33–2.30

   

 rs1042522

Cases vs NC

G/C

0.54

0.73

0.41–1.29

0.82

0.92

0.47–1.82

C/C

 

0.78

0.37–1.64

   

Cases vs OC

G/C

0.41

0.88

0.48–1.59

0.21

0.66

0.34–1.27

C/C

 

0.61

0.30–1.27

   

NC vs OC

G/C

0.51

1.21

0.65–2.24

0.32

0.71

0.36–1.39

C/C

 

0.79

0.37–1.67

   

Variable

Groups

Dominant model

Allele model

P-value

OR

95%CI

P-value

OR

95%CI

 rs25487

Cases vs NC

0.00*

2.30

1.37–3.86

0.00*

2.05

1.39–3.04

Cases vs OC

0.02*

1.88

1.10–3.22

0.00*

1.79

1.20–2.67

NC vs OC

0.47

0.82

0.48–1.40

0.53

0.87

0.57–1.34

 rs1042522

Cases vs NC

0.27

0.74

0.43–1.27

0.37

0.84

0.58–1.23

Cases vs OC

0.37

0.78

0.45–1.34

0.17

0.77

0.52–1.12

NC vs OC

0.87

1.05

0.59–1.86

0.64

0.91

0.62–1.34

  1. OR Odd ratio, CI Confidence interval, NC Negative controls, OC Elderly patients above the age of 80
  2. *indicated p-value< 0.05
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