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Table 3 Risk factors for biochemical recurrence-free survival

From: Free testosterone value before radical prostatectomy is related to oncologic outcomes and post-operative erectile function

Variables Univariate analysis Multivariate analysis
HR 95%CI p value HR 95%CI p value
Total T (normal vs low) 0.655 0.421–1.019 0.061    
Free T (normal vs low) 0.434 0.299–0.628 < 0.001* 0.564 0.377-0.843 0.005*
Age (continuous) 1.019 0.995–1.045 0.126    
BMI (continuous) 0.990 0.941–1.042 0.710    
Diabetes (presence vs absence) 0.888 0.549–1.436 0.628    
Hypertension (presence vs absence) 0.788 0.442–1.403 0.417    
Coronary heart disease (presence vs absence) 0.878 0.483–1.596 0.670    
Smoke (presence vs absence) 0.657 0.382–1.130 0.129    
Alcohol (presence vs absence) 0.982 0.646–1.493 0.931    
PSA (≥10 ng/ml vs < 10 ng/ml) 1.515 1.020–2.250 0.039* 1.261 0.835-1.904 0.270
Proportion of free-PSA (≥ 0.16 vs < 0.16) 0.794 0.527–1.196 0.296    
Surgical approach (laparoscopic vs open) 0.922 0.643–1.322 0.658    
NVB preserve(presence vs absence) 0.935 0.648–1.349 0.719    
Pathological Tumor stage (T2a vs T3) 0.270 0.116–0.626 0.002* 0.333 0.128-0.804 0.014*
Pathological Tumor stage (T2b vs T3) 0.414 0.252–0.677 < 0.001* 0.457 0.268-0.780 0.004*
Pathological Tumor stage (T2c vs T3) 0.633 0.415–0.966 0.034* 0.814 0.523-1.268 0.363
Final Gleason Score (6 vs 8 or higher) 0.316 0.173–0.577 < 0.001* 0.532 0.278-1.019 0.057
Final Gleason Score (7 vs 8 or higher) 0.518 0.353–0.761 0.001* 0.647 0.431-0.971 0.036*
Lymph node status (N- vs N+) 0.328 0.167–0.644 0.001* 0.523 0.259-1.054 0.070
Lymph node status (Nx vs N+) 0.407 0.215–0.768 0.006* 0.927 0.467-1.840 0.829
Seminal invasion (presence vs absence) 2.483 1.255–4.914 0.009* 1.048 0.497-2.211 0.902
PSM (presence vs absence) 2.350 1.453–3.803 0.001* 1.432 0.862-2.378 0.165
  1. HR Hazard Ratio; CI confidence interval; TT total testosterone; FT free testosterone; PSA prostate-specific antigen; BMI body mass index; PSM positive surgical margin; NVB neurovascular bundle
  2. p value of less than 0.05 are in boldface
  3. *Statistically significant