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Table 3 Risk factors for biochemical recurrence-free survival

From: Free testosterone value before radical prostatectomy is related to oncologic outcomes and post-operative erectile function

Variables

Univariate analysis

Multivariate analysis

HR

95%CI

p value

HR

95%CI

p value

Total T (normal vs low)

0.655

0.421–1.019

0.061

   

Free T (normal vs low)

0.434

0.299–0.628

< 0.001*

0.564

0.377-0.843

0.005*

Age (continuous)

1.019

0.995–1.045

0.126

   

BMI (continuous)

0.990

0.941–1.042

0.710

   

Diabetes (presence vs absence)

0.888

0.549–1.436

0.628

   

Hypertension (presence vs absence)

0.788

0.442–1.403

0.417

   

Coronary heart disease (presence vs absence)

0.878

0.483–1.596

0.670

   

Smoke (presence vs absence)

0.657

0.382–1.130

0.129

   

Alcohol (presence vs absence)

0.982

0.646–1.493

0.931

   

PSA (≥10 ng/ml vs < 10 ng/ml)

1.515

1.020–2.250

0.039*

1.261

0.835-1.904

0.270

Proportion of free-PSA (≥ 0.16 vs < 0.16)

0.794

0.527–1.196

0.296

   

Surgical approach (laparoscopic vs open)

0.922

0.643–1.322

0.658

   

NVB preserve(presence vs absence)

0.935

0.648–1.349

0.719

   

Pathological Tumor stage (T2a vs T3)

0.270

0.116–0.626

0.002*

0.333

0.128-0.804

0.014*

Pathological Tumor stage (T2b vs T3)

0.414

0.252–0.677

< 0.001*

0.457

0.268-0.780

0.004*

Pathological Tumor stage (T2c vs T3)

0.633

0.415–0.966

0.034*

0.814

0.523-1.268

0.363

Final Gleason Score (6 vs 8 or higher)

0.316

0.173–0.577

< 0.001*

0.532

0.278-1.019

0.057

Final Gleason Score (7 vs 8 or higher)

0.518

0.353–0.761

0.001*

0.647

0.431-0.971

0.036*

Lymph node status (N- vs N+)

0.328

0.167–0.644

0.001*

0.523

0.259-1.054

0.070

Lymph node status (Nx vs N+)

0.407

0.215–0.768

0.006*

0.927

0.467-1.840

0.829

Seminal invasion (presence vs absence)

2.483

1.255–4.914

0.009*

1.048

0.497-2.211

0.902

PSM (presence vs absence)

2.350

1.453–3.803

0.001*

1.432

0.862-2.378

0.165

  1. HR Hazard Ratio; CI confidence interval; TT total testosterone; FT free testosterone; PSA prostate-specific antigen; BMI body mass index; PSM positive surgical margin; NVB neurovascular bundle
  2. p value of less than 0.05 are in boldface
  3. *Statistically significant
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BMC Cancer

ISSN: 1471-2407

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