Risk of lung cancer in relation to various metrics of smoking history: a case-control study in Montreal

Remen, T.; Pintos, J.; Abrahamowicz, M.; Siemiatycki, J.

doi:10.1186/s12885-018-5144-5

BMC Cancer

Table 5 OR estimates between various smoking-related variables (categorical) and lung cancer risk by histology, males and females combined

From: Risk of lung cancer in relation to various metrics of smoking history: a case-control study in Montreal

				All histologies combined			Squamous cell carcinoma			Small cell carcinoma			Adenocarcinoma			Large cell carcinoma
Model	Cigarette smoking variables^a	Category	N (controls)	N (cases)	OR^b [95% CI]		N (cases)	OR^b [95% CI]		N (cases)	OR^b [95% CI]		N (cases)	OR^b [95% CI]		N (cases)	OR^b [95% CI]
Among all subjects (non-smokers being the reference group)
a	Ever smoking	No	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		Yes	1038	1150	9.56	[6.88 - 13.30]	340	9.44	[5.14 - 17.35]	205	Undefined		431	8.48	[5.46 - 13.17]	110	11.27	[3.94 - 32.18]
b	Smoking status	Non-smoker	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		Ex-smoker	648	318	4.47	[3.15 - 6.34]	115	4.99	[2.65 - 9.40]	39	Undefined		122	4.02	[2.51 - 6.44]	22	3.86	[1.25 - 11.88]
		Current smoker	390	832	17.59	[12.47 - 24.79]	225	17.38	[9.31 - 32.44]	166	Undefined		309	15.16	[9.62 - 23.89]	88	24.10	[8.25 - 70.37]
c	Duration of smoking	0	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		]0-30]	452	167	3.07	[2.11 - 4.47]	32	2.20	[1.09 - 4.44]	28	Undefined		76	3.00	[1.82 - 4.94]	19	3.81	[1.21 - 12.01]
		]30-40]	255	321	10.91	[7.57 - 15.74]	93	10.67	[5.58 - 20.39]	57			121	9.97	[6.10 - 16.27]	32	15.14	[4.92 - 46.58]
		>40	331	662	22.20	[15.42 - 31.96]	215	21.23	[11.21 - 40.20]	120			234	21.25	[12.99 - 34.75]	59	33.24	[10.52 - 105.05]
d	Intensity of smoking	0	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		]0-20]	420	201	4.79	[3.34 - 6.87]	43	3.59	[1.83 - 7.05]	39	Undefined		87	4.46	[2.75 - 7.22]	20	5.87	[1.90 - 18.10]
		]20-30]	374	550	14.12	[9.93 - 20.08]	148	13.80	[7.32 - 26.00]	90			231	14.26	[8.92 - 22.79]	54	18.03	[6.04 - 53.75]
		>30	244	399	15.31	[10.53 - 22.26]	149	17.59	[9.19 - 33.65]	76			113	11.22	[6.75 - 18.65]	36	17.20	[5.46 - 54.10]
e	Pack-years	0	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		]0-30]	423	119	2.94	[2.01 - 4.31]	28	2.52	[1.24 - 5.11]	19	Undefined		55	2.85	[1.71 - 4.76]	9	2.56	[0.74 - 8.84]
		]30-60]	370	505	13.60	[9.55 - 19.35]	118	11.08	[5.85 - 20.93]	82			229	14.50	[9.06 - 23.19]	50	19.28	[6.36 - 58.37]
		>60	245	526	24.16	[16.57 - 35.41]	194	26.40	[13.76 - 50.63]	104			147	17.96	[10.75 - 30.01]	51	40.61	[12.58 - 131.09]
f	CSI index	0	467	50	1	-	12	1	-	0	1	-	26	1	-	4	1	-
		]0-1]	316	49	1.64	[1.05 - 2.56]	11	1.20	[0.51 - 2.82]	5	Undefined		22	1.61	[0.87 - 2.96]	4	1.54	[0.36 - 6.51]
		]1-2]	438	369	8.19	[5.76 - 11.64]	101	7.96	[4.20 - 15.07]	59			155	7.79	[4.86 - 12.47]	36	10.87	[3.58 - 33.01]
		>2	284	732	24.68	[17.22 - 35.37]	228	23.90	[12.68 - 45.04]	141			254	22.50	[13.91 - 36.39]	70	37.04	[12.03 - 114.04]

This table presents the association between each smoking-related (categorical) variable and the logit of the lung cancer risk by histology
^aComputed after a discount up to 2 years when relevant
^bOdds ratio [OR] adjusted for age, sex, respondent type, education, ethnic group, annual income and exposure to lung carcinogens [each exposure being considered separately

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ISSN: 1471-2407

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