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Table 3 Characteristics of patients from whom cancer tissue was obtained

From: PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD)

 

Non-smoker

Healthy Smoker

COPD

p value

n

7

11

11

NS

Age (years)

73.9 ± 10.5

65.4 ± 2.4

69.6 ± 2.1

NS

Male (% group)

40

46

62

NS

Smoking index (pack-year)

N/A

51 ± 17.4

66 ± 21

NS

FEV1

1.9 ± 0.4

2.3 ± 0.2

2.0 ± 0.2

NS

% predicted FEV1

89.2 ± 3.3

87.8 ± 3.6

77.9 ± 4.7

< 0.05

FVC

2.3 ± 0.7

3.0 ± 0.2

3.5 ± 0.4

< 0.05

% predicted FVC

103.8 ± 5.8

95.9 ± 5.9

103.5 ± 2.6

NS

FEV1/ FVC (%)

76.3 ± 9.8

76.1 ± 1.3

58.3 ± 2.9

< 0.05

Emphysema present / Emphysema status known

0/7

5/10

8/10

< 0.05

Cancer Histology

6 ADC,

1 SCC

5 ADC, 6 SCC

2 ADC,

8 SCC,

1 NSCLC

< 0.05

Cancer Stage

3 Stage1

4 Stage2

8 Stage1

3 Stage 2

8 Stage 1

2 Stage 2

1 Stage 3

NS

  1. Kruskal-Wallis test was used, with one-way ANOVA tests across the three groups of subjects and Dunn’s multiple comparison tests between the groups. NS = not significant (p > 0.05)
  2. ADC adenocarcinoma, SCC squamous cell carcinoma, NSCLC non small cell carcinoma not otherwise specified. Emphysema status was determined by histology of non-cancerous lung from the same lobe as the cancer