PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD)

Table 2 Differentially-expressed mitochondrial-related genes between normal and cancer tissue and association with patient survival

	Squamous cell carcinoma	Fold change	Hazard Ratio	Adenocarcinoma	Fold change	Hazard ratio
Oxidative phosphorylation complex	Ndufs1	5	1.5	Ndufs1	4	1.6
	Ndufv1	2.9	1.1	Ndufa9	2.4	1.8
	Bcs1L	7	1.2	ATP5G1	7.5	3.2
	ATP5i	4.8	1.4	ATP5J2	3.7	2.3
Mitophagy	PGAM 5	2.5	3.1
Glycolysis				ENO 1	2	2.7
				ENO2	3.5	1.9
				Aldo A	2.6	7.3
Necroptosis	FADD	2.2	2.3
Anti-oxidants				GPX 2	74	1.2
Autophagy				LRPPRC	3	1.7

The differential expression of genes between cancer and the normal surrounding tissue was obtained from the publicly-available RNA Seq Nexus database [17] [http://syslab4.nchu.edu.tw/]. The genes with ≥2 fold change of expression in cancer versus normal tissue expression were selected, (all at p < 0.05). The effect of gene expression on patient outcome was also assessed using the Precog database. The genes shown are associated with increased mortality of NSCLC patients, with the hazard ratio shown in Precog

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