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Table 2 Univariate and multivariate analyses of clinicopathological data and A-FABP expression in relation to EFS and OS of patients with urothelial carcinoma

From: Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up

  Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
mEFS 95% CI p HR 95% CI p mOS 95% CI p HR 95% CI p
+ + + +
Sex
 Male 29.3 17.1 41.5 0.371   128.4 91.9 165.0 0.696  
 Female 33.2 0.0 88.0 not reached    
Median Age
  ≤ 72 years 41.9 6.3 77.4 0.005 1.6 1.1 2.2 0.01 not reached    0.002 2.0 1.3 3.2 0.002
  > 72 years 17.5 4.5 30.4 72.3 48.0 96.6
Histology
 Papillary 30.5 14.2 46.9 0.702   149.3 108.1 190.5 0.032  
 Variants 29.6 27.1 32.2 33.2 28.1 38.2
pT
 pTa 72.3 34.8 109.8 < 0.001 1.4 1.1 1.7 0.003 not reached    < 0.001 2.1 1.6 2.9 < 0.001
 pT1 14.8 7.7 22.0 81.3 47.1 115.5
 pT2–4 15.9 11.2 20.6 18.0 7.1 29.0
pN
 0 34.9 16.5 53.2 0.005   154.2 107.8 200.5 < 0.001 2.1 1.1 4.0 0.028
 1–2 15.2 6.7 23.7 15.2 6.7 23.7
pM
 0 33.2 20.4 45.9 0.059   149.3 110.4 188.3 < 0.001  
 1 16.5 3.7 29.3 16.5 3.7 29.3
Grade
 PUNLMP not reached    0.002   not reached    < 0.001  
 LG-UC 35.9 7.9 63.9 178.5 122.5 234.6
 HG-UC 17.5 10.2 24.8 56.3 25.6 87.1
Cis
 no 30.5 19.1 42.0 0.258   128.7 89.4 167.9 0.789  
 yes 81.3 0 181.4 81.3 0 166.4
A-FABP
 negative 17.5 9.9 25.0 0.001   76.7 50.0 103.5 0.009  
 positive 62.5 1.8 123.2 154.2 114.9 193.4
  1. Abbreviations: EFS Event-free survival, OS Overall survival, PUNLMP Papillary urothelial neoplasm of low malignant potential, LG-UC Low grade urothelial carcinoma, HG-UC High grade urothelial carcinoma, Cis In situ carcinoma
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