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Table 2 Univariate and multivariate analyses of clinicopathological data and A-FABP expression in relation to EFS and OS of patients with urothelial carcinoma

From: Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up

 

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

mEFS

95% CI

p

HR

95% CI

p

mOS

95% CI

p

HR

95% CI

p

–

+

–

+

–

+

–

+

Sex

 Male

29.3

17.1

41.5

0.371

 

128.4

91.9

165.0

0.696

 

 Female

33.2

0.0

88.0

not reached

   

Median Age

  ≤ 72 years

41.9

6.3

77.4

0.005

1.6

1.1

2.2

0.01

not reached

  

0.002

2.0

1.3

3.2

0.002

  > 72 years

17.5

4.5

30.4

72.3

48.0

96.6

Histology

 Papillary

30.5

14.2

46.9

0.702

 

149.3

108.1

190.5

0.032

 

 Variants

29.6

27.1

32.2

33.2

28.1

38.2

pT

 pTa

72.3

34.8

109.8

< 0.001

1.4

1.1

1.7

0.003

not reached

  

< 0.001

2.1

1.6

2.9

< 0.001

 pT1

14.8

7.7

22.0

81.3

47.1

115.5

 pT2–4

15.9

11.2

20.6

18.0

7.1

29.0

pN

 0

34.9

16.5

53.2

0.005

 

154.2

107.8

200.5

< 0.001

2.1

1.1

4.0

0.028

 1–2

15.2

6.7

23.7

15.2

6.7

23.7

pM

 0

33.2

20.4

45.9

0.059

 

149.3

110.4

188.3

< 0.001

 

 1

16.5

3.7

29.3

16.5

3.7

29.3

Grade

 PUNLMP

not reached

  

0.002

 

not reached

  

< 0.001

 

 LG-UC

35.9

7.9

63.9

178.5

122.5

234.6

 HG-UC

17.5

10.2

24.8

56.3

25.6

87.1

Cis

 no

30.5

19.1

42.0

0.258

 

128.7

89.4

167.9

0.789

 

 yes

81.3

0

181.4

81.3

0

166.4

A-FABP

 negative

17.5

9.9

25.0

0.001

 

76.7

50.0

103.5

0.009

 

 positive

62.5

1.8

123.2

154.2

114.9

193.4

  1. Abbreviations: EFS Event-free survival, OS Overall survival, PUNLMP Papillary urothelial neoplasm of low malignant potential, LG-UC Low grade urothelial carcinoma, HG-UC High grade urothelial carcinoma, Cis In situ carcinoma
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BMC Cancer

ISSN: 1471-2407

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