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Table 2 Differentially expressed heparan sulfate proteoglycans and heparan sulfate binding proteins

From: Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells

Category Gene Symbol Gene Name Foldchange
Heparan Sulfate Proteoglycans COL12A1 collagen, type XII, alpha 1 3.09
GPC4 glypican 4 2.85
GPC3 glypican 3 2.78
SRGN serglycin 2.34
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2.10
GPC2 glypican 2 1.96
SDC4 syndecan 4 1.23
SDC2 syndecan 2 1.22
COL9A1 collagen, type IX, alpha 1 1.20
SDC1 syndecan 1 −1.34
Heparan Sulfate
Proteoglycan
Binding Proteins
SERPINE2 serpin family E member 2 4.10
BMP4 bone morphogenetic protein 4 3.95
THBS1 thrombospondin 1 3.73
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 3.58
Laminin laminin, beta 1 3.49
LPL lipoprotein lipase 3.44
CCL2 chemokine (C-C motif) 3.35
SFRP1 secreted frizzled-related protein 1 3.25
LAMA1 laminin, alpha 1 3.16
FGFR2 fibroblast growth factor receptor 2 2.92
FSTL1 follistatin-like 1 2.62
NAV2 neuron navigator 2 2.42
PGF placental growth factor 2.31
CYR61 cysteine-rich, angiogenic inducer, 61 1.93
ANOS1 anosmin 1 1.77
FGF12 fibroblast growth factor 12 1.64
REG4 regenerating islet-derived family, member 4 1.56
HBEGF heparin-binding EGF-like growth factor 1.44
TGFBR3 transforming growth factor, beta receptor III 1.42
WNT4 wingless-type MMTV integration site family, member 4 1.38
FBN1 fibrillin 1 1.30
LIPH lipase, member H 1.16
NCAM neural cell adhesion molecule 1 1.15
COL5A3 collagen, type V, alpha 3 1.05
FGF10 fibroblast growth factor 10 −2.37
HDGF hepatoma-derived growth factor −1.51
FGF2 fibroblast growth factor 2 (basic) −1.20
ZNF146 zinc finger protein 146 −1.19
AGER advanced glycosylation end product-specific receptor −1.18
PCOLCE2 procollagen C-endopeptidase enhancer 2 −1.16
PCSK6 proprotein convertase subtilisin/kexin type 6 −1.09
  1. Within the microarray data, genes coding for multiple HSPGs and their binding partners are significantly differentially expressed after HDAC inhibitor treatment