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Table 2 Differentially expressed heparan sulfate proteoglycans and heparan sulfate binding proteins

From: Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells

Category

Gene Symbol

Gene Name

Foldchange

Heparan Sulfate Proteoglycans

COL12A1

collagen, type XII, alpha 1

3.09

GPC4

glypican 4

2.85

GPC3

glypican 3

2.78

SRGN

serglycin

2.34

SPOCK1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan

2.10

GPC2

glypican 2

1.96

SDC4

syndecan 4

1.23

SDC2

syndecan 2

1.22

COL9A1

collagen, type IX, alpha 1

1.20

SDC1

syndecan 1

−1.34

Heparan Sulfate

Proteoglycan

Binding Proteins

SERPINE2

serpin family E member 2

4.10

BMP4

bone morphogenetic protein 4

3.95

THBS1

thrombospondin 1

3.73

ADAMTS15

ADAM metallopeptidase with thrombospondin type 1 motif, 15

3.58

Laminin

laminin, beta 1

3.49

LPL

lipoprotein lipase

3.44

CCL2

chemokine (C-C motif)

3.35

SFRP1

secreted frizzled-related protein 1

3.25

LAMA1

laminin, alpha 1

3.16

FGFR2

fibroblast growth factor receptor 2

2.92

FSTL1

follistatin-like 1

2.62

NAV2

neuron navigator 2

2.42

PGF

placental growth factor

2.31

CYR61

cysteine-rich, angiogenic inducer, 61

1.93

ANOS1

anosmin 1

1.77

FGF12

fibroblast growth factor 12

1.64

REG4

regenerating islet-derived family, member 4

1.56

HBEGF

heparin-binding EGF-like growth factor

1.44

TGFBR3

transforming growth factor, beta receptor III

1.42

WNT4

wingless-type MMTV integration site family, member 4

1.38

FBN1

fibrillin 1

1.30

LIPH

lipase, member H

1.16

NCAM

neural cell adhesion molecule 1

1.15

COL5A3

collagen, type V, alpha 3

1.05

FGF10

fibroblast growth factor 10

−2.37

HDGF

hepatoma-derived growth factor

−1.51

FGF2

fibroblast growth factor 2 (basic)

−1.20

ZNF146

zinc finger protein 146

−1.19

AGER

advanced glycosylation end product-specific receptor

−1.18

PCOLCE2

procollagen C-endopeptidase enhancer 2

−1.16

PCSK6

proprotein convertase subtilisin/kexin type 6

−1.09

  1. Within the microarray data, genes coding for multiple HSPGs and their binding partners are significantly differentially expressed after HDAC inhibitor treatment