Biosynthetic & other metabolic processes | ||
---|---|---|
Log2 Fold-change | Symbol | Gene Name |
Multiple Pathways | ||
 −1.26 | FUT10 | |
 −1.26 | FUT11 | |
 −1.56 | B4GALT2 | UDP-Gal:β-GlcNAc β-(1,4)-galactosyltransferase 2 [50] |
 1.07 | B3GAT2 | β-(1,3)-glucuronyltransferase 2 |
Glycoprotein | ||
EGF Domain | ||
 −1.04 | POGLUT1 | |
 1.30 | LFNG | |
N & O-Linked Pathways | ||
 1.56 | B3GNT2 | N-acetyllactosaminide β-(1,3)-GlcNAc transferase 2 [50, 55] |
Complex N-Linked Pathway | ||
 −1.10 | ALG13 | UDP-GlcNAc transferase subunit [50] |
 −1.09 | ALG10 | α-1,2-glucosyltransferase [56] |
 5.16 | MAN1A1 | |
 1.63 | MGAT4A | α-(1,3)-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase A [50, 56] |
Complex O-linked Pathway | ||
 −1.28 | GALNT14 | |
 1.00 | GALNT6 | |
 −1.08 | GALNT7 | |
 1.79 | GCNT1 | β-(1,3)-galactosyl-O-glycosyl-glycoprotein β-1,6-GlcNAc transferase [50, 61, 62] |
O-linked GAG synthesis | ||
Core tetrasaccharide linker for HSPG, Chondroitin Sulfate, Dermatan sulfate | ||
 2.85 | XYLT1 | |
 −1.36 | B3GALT6 | UDP-Gal:βGal β-(1,3)-Gal transferase polypeptide 6 (GALT2) |
Chondroitin Sulfate | ||
 1.85 | CGAT1 | Chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
HSPGs | ||
 1.10 | EXT1 | Exostosin glycosyltransferase 1 [50] |
 −2.22 | NDST1 | N-deacetylase/N-sulfotransferase [50] |
 1.30 | GLCE | |
Glycolipid metabolism | ||
 1.07 | KDEL1 | KDEL motif-containing protein 1 [50] |
 1.07 | KDEL2 | KDEL motif-containing protein 2 [50] |
Sphingolipid & Gangliosides (lactosylceramide modification) | ||
 1.57 | A4GALT | α-(1,4)-galactosyltransferase [50] |
 1.46 | ST3GAL5 | ST3 β-galactoside α-(2,3)-sialyltransferase 5 [50] |
 2.80 | ST8SIA1 | ST8 (α-N-acetyl-neuraminide α-(2,8) sialyltransferase 1) |
 1.30 | ST6GALNAC3 | ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3) |
GPI Anchor synthesis | ||
 1.10 | PIGH | Phosphatidylinositol GlcNAc transferase subunit H [50] |
 −1.67 | PIGW | Phosphatidylinositol-glycan biosynthesis class W protein |
 −1.21 | PIGO | GPI ethanolamine phosphate transferase 3 [50] |
 −1.13 | PIGU | Phosphatidylinositol glycan anchor biosynthesis class U protein [50] |
Polysialic acid | ||
 2.71 | ST6GAL2 / SIAT2 | ST6 β-galactosamide α-2,6-sialyltranferase 2 |
 1.27 | ST8SIA4 / SIA8D | ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 [50] |
Sulfation levels | ||
General enzymes | ||
 1.11 | PAPSS1 | 3′-phosphoadenosine 5′-phosphosulfate synthase 1 [50] |
 −1.09 | CHST10 | carbohydrate sulfotransferase 10 [50] |
Sulfatases (HSPG) | ||
 2.94 | SULF1 | |
 1.11 | SULF2 | |
Protein sulfotransferase | ||
 1.00 | TPST2 | Tyrosylprotein sulfotransferase 2 [50] |
Lipid sulfotransferases - sphingolipid/ceramide | ||
 1.38 | GAL3ST1 | |
N&O linked sulfotransferases | ||
 1.35 | CHST8 | Carbohydrate (N-acetylgalactosamine 4–0) sulfotransferase 8 |
 −1.67 | CHST9 | Carbohydrate (N-acetylgalactosamine 4–0) sulfotransferase 9 [71,72,73] |
Chondroitin / Dermatan sulfate | ||
 1.25 | CHST11 | Carbohydrate (chondroitin 4) sulfotransferase 11 (C4ST-1) [50] |
 1.05 | CHST12 | Carbohydrate (chondroitin 4) sulfotransferase 12 [50] |
 − 1.42 | CHST14 | Carbohydrate (dermatan 4) sulfotransferase 14 |
 2.58 | GAL3ST4 | Galactose-3-O-sulfotransferase 4 [50] |
Catabolic enzymes | ||
Lysomal enzymes | ||
 1.39 | NEU1 | Neuraminidase 1 (lysosomal sialidase) |
 2.80 | FUCA1 | Fucosidase, α-L- 1, tissue [52] |
Glycoprotein Unibiquitin ligases (ERAD pathway) | ||
 1.03 | FBXO2 | F-box only protein 2 [50] |
 −3.01 | FBXO6 | F-box only protein 6 [50] |
 −1.66 | FBXO17 | F-box only protein 17 [50] |
Metabolic enzymes | ||
 1.67 | GALM | Galactose mutarotase [50] |