Fig. 2
Metabolic description of the tumors using [18F]FDG and Na[18F]F. Representative PET studies obtained in orthotopic models of osteosarcoma. A and B images correspond to the same animal injected with 531MII cell line, whereas C and D images were obtained from other animal injected with 143B line. The use of [18F]FDG (a, c) or Na[18F]F (b, c) allowed detection of different metabolic patterns in the tumors. Images from sections stained with hematoxylin-eosin from each tumor (e, f, g) confirmed that the 531MII cell line created heterogeneous tumors with osteoblastic or osteolytic phenotypes, whereas the 143B model generated osteolytic tumors with high cellularity. Red arrows: tumors detected by PET; asterisk: physiological utptake of Na[18F]F in knees; b: bladder showing physiological excretion of radiotracer