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Table 1 Summary of the genetic findings in glioma cases that recurred, progressed to HGG or presented a de novo tumor

From: BRAF V600E mutation and 9p21: CDKN2A/B and MTAP co-deletions - Markers in the clinical stratification of pediatric gliomas

  Patient N° / Condition Time of Biopsy / Surgery Age (years) Location Diagnosis BRAFV600E Mutation 9p21 Chromosomal Region Deletion (9p21 region//centromere of chromosome 9) Follow-up
1 LGG3 1992 < 3 Hypothalamus/Optic Chiasm Pilocytic Astrocytoma Negative Negative Alive, 2015
LGG10 2009 > 8 Hypothalamus/Optic Chiasm Pilocytic Astrocytoma Negative Negative
2 LGG68 1995 3–8 Hypothalamus/Optic Chiasm Diffuse Astrocytoma Positive ND Alive, 2015
  LGG29 1996 3–8 Cerebral Cortex Pilocytic Astrocytoma Negative Negative
  LGG5 1999 3–8 Hypothalamus/Optic Chiasm Pilocytic Astrocytoma Positive Negative
3 LGG40 2000 3–8 Brainstem Pilocytic Astrocytoma Negative ND Alive, 2015
  LGG41 2002 3–8 Brainstem Pilocytic Astrocytoma Negative ND
4 LGG34 2011 3–8 Diencephalon Pilocytic Astrocytoma Negative ND Alive, 2015
  LGG48 2013 3–8 Unknown Pilocytic Astrocytoma ND ND
5 LGG82 1996 3–8 Cerebellum Pilocytic Astrocytoma Negative ND Death, 2010
  HGG9 2009 > 8 Cerebellum Anaplastic Astrocytoma Negative Positive
6 LGG54 2009 3–8 Cerebral Cortex Ganglioglioma Positive Negative Alive, 2015
  LGG53 2014 > 8 Cerebral Cortex Ganglioglioma Positive Negative
7 LGG2 2013 > 8 Hypothalamus / Optic Chiasm Pilocytic Astrocytoma Negative ND Alive, 2015
  LGG9 2015 > 8 Hypothalamus / Optic Chiasm Pilocytic Astrocytoma Negative ND
8 LGG36 2014 > 8 Dienchephalon Pilocytic Astrocytoma Negative ND Alive, 2015
  LGG37 2015 > 8 Hippocampus Pilocytic Astrocytoma Negative Positive
9 LGG81 2011 3–8 Cerebral Cortex Pleomorphic Xanthoastrocytoma Positive Positive Death, 2014
  HGG23 2013 > 8 Cerebral Cortex Glioblastoma Positive Positive
  1. LGG Low-grade Glioma,HGG High-grade glioma, ND Not Done
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