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Table 1 Summary of the genetic findings in glioma cases that recurred, progressed to HGG or presented a de novo tumor

From: BRAF V600E mutation and 9p21: CDKN2A/B and MTAP co-deletions - Markers in the clinical stratification of pediatric gliomas

 

Patient N° / Condition

Time of Biopsy / Surgery

Age (years)

Location

Diagnosis

BRAFV600E Mutation

9p21 Chromosomal Region Deletion (9p21 region//centromere of chromosome 9)

Follow-up

1

LGG3

1992

< 3

Hypothalamus/Optic Chiasm

Pilocytic Astrocytoma

Negative

Negative

Alive, 2015

LGG10

2009

> 8

Hypothalamus/Optic Chiasm

Pilocytic Astrocytoma

Negative

Negative

2

LGG68

1995

3–8

Hypothalamus/Optic Chiasm

Diffuse Astrocytoma

Positive

ND

Alive, 2015

 

LGG29

1996

3–8

Cerebral Cortex

Pilocytic Astrocytoma

Negative

Negative

 

LGG5

1999

3–8

Hypothalamus/Optic Chiasm

Pilocytic Astrocytoma

Positive

Negative

3

LGG40

2000

3–8

Brainstem

Pilocytic Astrocytoma

Negative

ND

Alive, 2015

 

LGG41

2002

3–8

Brainstem

Pilocytic Astrocytoma

Negative

ND

4

LGG34

2011

3–8

Diencephalon

Pilocytic Astrocytoma

Negative

ND

Alive, 2015

 

LGG48

2013

3–8

Unknown

Pilocytic Astrocytoma

ND

ND

5

LGG82

1996

3–8

Cerebellum

Pilocytic Astrocytoma

Negative

ND

Death, 2010

 

HGG9

2009

> 8

Cerebellum

Anaplastic Astrocytoma

Negative

Positive

6

LGG54

2009

3–8

Cerebral Cortex

Ganglioglioma

Positive

Negative

Alive, 2015

 

LGG53

2014

> 8

Cerebral Cortex

Ganglioglioma

Positive

Negative

7

LGG2

2013

> 8

Hypothalamus / Optic Chiasm

Pilocytic Astrocytoma

Negative

ND

Alive, 2015

 

LGG9

2015

> 8

Hypothalamus / Optic Chiasm

Pilocytic Astrocytoma

Negative

ND

8

LGG36

2014

> 8

Dienchephalon

Pilocytic Astrocytoma

Negative

ND

Alive, 2015

 

LGG37

2015

> 8

Hippocampus

Pilocytic Astrocytoma

Negative

Positive

9

LGG81

2011

3–8

Cerebral Cortex

Pleomorphic Xanthoastrocytoma

Positive

Positive

Death, 2014

 

HGG23

2013

> 8

Cerebral Cortex

Glioblastoma

Positive

Positive

  1. LGG Low-grade Glioma,HGG High-grade glioma, ND Not Done