Skip to main content

Table 2 Cox regression analysis of prognostic factors for HCC patients

From: SKA1 overexpression is associated with poor prognosis in hepatocellular carcinoma

Variables

OS

RFS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Gender(male/female)

1.355 (0.537–3.416)

0.520

  

1.621 (0.652–4.031)

0.299

  

Age (> 53/≤53 years)

1.446 (0.827–2.527)

0.195

  

1.990 (1.970–2.011)

0.454

  

Tumor size (> 5/≤5 cm)

2.275 (1.296–3.994)

0.004

  

2.603 (1.583–4.281)

0.001

  

Differentiation (poor/well to moderate)

1.835 (0.954–3.530)

0.069

  

1.213 (0.721–2.040)

0.466

  

HBsAg (positive/negative)

1.323 (0.526–3.328)

0.552

  

1.147 (0.524–2.509)

0.731

  

AFP (≥200/< 200 μg/L)

1.000 (1.081–3.281)

0.025

1.395 (0.782–2.489)

0.260

1.912 (1.183–3.090)

0.008

1.449 (0.857–2.450)

0.167

TNM stage (III + IV/I + II)

1.516 (1.156–1.987)

0.003

1.962 (1.196–3.684)

0.031

1.688 (1.337–3.131)

0.001

1.472 (1.131–1.916)

0.004

SKA1 expression (positive/negative)

2.497 (1.380–4.516)

0.002

2.133 (1.145–3.974)

0.017

1.974 (1.208–3.224)

0.007

1.750 (1.064–2.878)

0.028

  1. AFP, α-fetoprotein; CI, confidence interval, HBsAg; hepatitis B virus surface antigen; HCC, hepatocellular carcinoma; HR, hazard ratio; OS, overall survival; RFS, relapse-free survival