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Fig. 4 | BMC Cancer

Fig. 4

From: Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma

Fig. 4

Mutational signatures of LUAD cohort. Box plot summarizing the SNV and box plot of Ti and Tv in the LUAD E19del-subgroup (a) and in the LUAD SNV-subgroup (b). Mutational signature plot derived from a 47 X 96 matrix analyzed using the NMF, which had 37 mEGFR -positive TCGA-LUAD cases (c) and bar graph indicating the degree to which each case contributed to the individual mutational signature (d). Mutational signatures obtained from the E19del- subgroup (e) and LUAD SNV-subgroup (f). *n.s. not significant. ** P-value was obtained by Wilcoxon signed rank test

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