Fig. 3

Modulation of tumorigenesis in the MMTV-PyVT transgenic model for human luminal breast cancer. (a) Disease-free survival curves for MMTV-PyVT;MD+/+ (n = 15), MMTV-PyVT;MD+/− (n = 16) and MMTV-PyVT;MD−/− (n = 18) mice. Log-rank test P-values are shown. (b) Average age at the appearance of the first palpable tumor. (c) Average tumor multiplicity at necropsy. (d) Tumor growth plot graphing average diameter size (in mm) versus weeks after first appearance. (e) Average age at end point. (f) Average amount of lung macro-metastatic foci (left panel). Average amount of lung micro-metastatic foci (right panel). * = p < 0.05, **p < 0.01