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Table 2 The concentration of flavonoid necessary for 50% inhibition (IC50 values) for cell viability was revealed. Mean ± SEM are from four analytical experiments which were performed in triplicate. bFR: fold-drug resistance was derived by dividing the IC50 concentration for doxorubicin of MCF-7 and MCF-7/ADR cells in the absence/presence of theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin by the IC50 concentration for doxorubicin of MCF-7 cells

From: RETRACTED ARTICLE:Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

Compound

MCF-7

MCF-7/ADR

IC50 ± SEMα (μM)

FRb

IC50 ± SEMα (μΜ)

FRb

Doxorubicin

0.32 ± 0.01

[1.0]

8.57 ± 0.23

[26.78]

+ 1 μM Theaflavine

0.32 ± 0.02

[1.0]

5.31 ± 0.04

[16.57]

+ 5 μM Theaflavine

0.29 ± 0.01

[0.9]

3.12 ± 0. 03

[9.75]

+ 10 μM Theaflavine

0.27 ± 0.01

[0.8]

0.8 ± 0.02

[2.5]

+ 1 μM Quercetin

0.31 ± 0.02

[0.9]

5.9 ± 0.05

[18.43]

+ 5 μM Quercetin

0..29 ± 0.02

[0.9]

3.41 ± 0.01

[10.65]

+ 10 μM Quercetin

0.28 ± 0.01

[0.8]

1.1 ± 0.01

[3.43]

+ 1 μM Rutin

0.32 ± 0.03

[1.0]

6.8 ± 0.05

[21.25]

+ 5 μM Rutin

0.30 ± 0.01

[0.9]

4.5 ± 0.01

[14.06]

+ 10 μM Rutin

0.28 ± 0.01

[0.8]

1.6 ± 0.01

[5.0]

+ 1 μM E3G

0.32 ± 0.02

[1.0]

6 ± 0.04

[18.75]

+ 5 μM E3G

0.31 ± 0.01

[0.9]

3.8 ± 0.02

[11.87]

+ 10 μM E3G

0.29 ± 0.02

[0.8]

1 ± 0.02

[3.12]

+ 1 μM Tamarixetin

0.32 ± 0.02

[0.8]

7.3 ± 0.03

[22.81]

+ 5 μM Tamarixetin

0.31 ± 0.02

[0.5]

4.9 ± 0.02

[15.31]

+ 10 μM Tamarixetin

0.30 ± 0.01

[0.5]

2.53 ± 0.01

[7.9]