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Table 2 The concentration of flavonoid necessary for 50% inhibition (IC50 values) for cell viability was revealed. Mean ± SEM are from four analytical experiments which were performed in triplicate. bFR: fold-drug resistance was derived by dividing the IC50 concentration for doxorubicin of MCF-7 and MCF-7/ADR cells in the absence/presence of theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin by the IC50 concentration for doxorubicin of MCF-7 cells

From: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

Compound MCF-7 MCF-7/ADR
IC50 ± SEMα (μM) FRb IC50 ± SEMα (μΜ) FRb
Doxorubicin 0.32 ± 0.01 [1.0] 8.57 ± 0.23 [26.78]
+ 1 μM Theaflavine 0.32 ± 0.02 [1.0] 5.31 ± 0.04 [16.57]
+ 5 μM Theaflavine 0.29 ± 0.01 [0.9] 3.12 ± 0. 03 [9.75]
+ 10 μM Theaflavine 0.27 ± 0.01 [0.8] 0.8 ± 0.02 [2.5]
+ 1 μM Quercetin 0.31 ± 0.02 [0.9] 5.9 ± 0.05 [18.43]
+ 5 μM Quercetin 0..29 ± 0.02 [0.9] 3.41 ± 0.01 [10.65]
+ 10 μM Quercetin 0.28 ± 0.01 [0.8] 1.1 ± 0.01 [3.43]
+ 1 μM Rutin 0.32 ± 0.03 [1.0] 6.8 ± 0.05 [21.25]
+ 5 μM Rutin 0.30 ± 0.01 [0.9] 4.5 ± 0.01 [14.06]
+ 10 μM Rutin 0.28 ± 0.01 [0.8] 1.6 ± 0.01 [5.0]
+ 1 μM E3G 0.32 ± 0.02 [1.0] 6 ± 0.04 [18.75]
+ 5 μM E3G 0.31 ± 0.01 [0.9] 3.8 ± 0.02 [11.87]
+ 10 μM E3G 0.29 ± 0.02 [0.8] 1 ± 0.02 [3.12]
+ 1 μM Tamarixetin 0.32 ± 0.02 [0.8] 7.3 ± 0.03 [22.81]
+ 5 μM Tamarixetin 0.31 ± 0.02 [0.5] 4.9 ± 0.02 [15.31]
+ 10 μM Tamarixetin 0.30 ± 0.01 [0.5] 2.53 ± 0.01 [7.9]