Compound | MCF-7 | MCF-7/ADR | ||
---|---|---|---|---|
IC50 ± SEMα (μM) | FRb | IC50 ± SEMα (μΜ) | FRb | |
Doxorubicin | 0.32 ± 0.01 | [1.0] | 8.57 ± 0.23 | [26.78] |
+ 1 μM Theaflavine | 0.32 ± 0.02 | [1.0] | 5.31 ± 0.04 | [16.57] |
+ 5 μM Theaflavine | 0.29 ± 0.01 | [0.9] | 3.12 ± 0. 03 | [9.75] |
+ 10 μM Theaflavine | 0.27 ± 0.01 | [0.8] | 0.8 ± 0.02 | [2.5] |
+ 1 μM Quercetin | 0.31 ± 0.02 | [0.9] | 5.9 ± 0.05 | [18.43] |
+ 5 μM Quercetin | 0..29 ± 0.02 | [0.9] | 3.41 ± 0.01 | [10.65] |
+ 10 μM Quercetin | 0.28 ± 0.01 | [0.8] | 1.1 ± 0.01 | [3.43] |
+ 1 μM Rutin | 0.32 ± 0.03 | [1.0] | 6.8 ± 0.05 | [21.25] |
+ 5 μM Rutin | 0.30 ± 0.01 | [0.9] | 4.5 ± 0.01 | [14.06] |
+ 10 μM Rutin | 0.28 ± 0.01 | [0.8] | 1.6 ± 0.01 | [5.0] |
+ 1 μM E3G | 0.32 ± 0.02 | [1.0] | 6 ± 0.04 | [18.75] |
+ 5 μM E3G | 0.31 ± 0.01 | [0.9] | 3.8 ± 0.02 | [11.87] |
+ 10 μM E3G | 0.29 ± 0.02 | [0.8] | 1 ± 0.02 | [3.12] |
+ 1 μM Tamarixetin | 0.32 ± 0.02 | [0.8] | 7.3 ± 0.03 | [22.81] |
+ 5 μM Tamarixetin | 0.31 ± 0.02 | [0.5] | 4.9 ± 0.02 | [15.31] |
+ 10 μM Tamarixetin | 0.30 ± 0.01 | [0.5] | 2.53 ± 0.01 | [7.9] |