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Fig. 4 | BMC Cancer

Fig. 4

From: Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats

Fig. 4

Effects of acyclic retinoid (ACR) and angiotensin-II receptor blocker (ARB) on liver steatosis, oxidative stress and inflammation. a-c Hepatic levels of triglyceride (TG) (a), 4-Hydroxynonenal (4-HNE) (b) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) (c) in experimental rats. d-h Relative mRNA expression levels of rat Tnfa (d), Il6 (e), Il1b (f), Ccl2 (g) and Serpine1 (h) in the liver of experimental rats. LETO; Long-Evans Tokushima Otsuka rat, OLETF; Otsuka Long-Evans Tokushima Fatty rat. 4-HNE and 8-OHdG levels are indicated as ratio to LETO control group (b and c). Relative mRNA expression levels were measured by quantitative RT–PCR (qRT–PCR), and GAPDH was used as internal control for qRT–PCR (d-h). Data are mean ± SD (n = 10). *, P ≤ 0.01 between each group

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