Skip to main content

Table 2 Hazard ratio (HR) for death with 95% confidence intervals (CI) using Cox proportional hazards models

From: Can pre-diagnostic serum levels of sodium and potassium predict prostate cancer survival?

Variables

Prostate Cancer specific mortality

Overall mortality

Cardiovascular mortality

Crude

Adjusted a

Adjusted b

Crude

Adjusted a

Adjusted b

Crude

Adjusted a

Adjusted b

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Events

1649

1003

3995

2234

485

302

Sodium (mEq/L)

Medical cut offs

< 136

1.12 (0.82–1.53)

1.14 (0.84–1.57)

1.15 (0.75–1.75)

1.16 (0.95–1.42)

1.20 (0.99–1.46)

1.14 (0.86–1.51)

1.21 (0.70–2.11)

1.29 (0.75–2.25)

0.82 (0.34–1.98)

136–145

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

> 145

1.08 (0.88–1.32)

1.11 (0.90–1.35)

1.08 (0.84–1.39)

1.00 (0.88–1.14)

1.04 (0.91–1.19)

1.06 (0.89–1.26)

0.75 (0.49–1.17)

0.81 (0.52–1.25)

0.84 (0.49–1.44)

Potassium (mEq/L)

Medical cut offs

< 3.5

0.65 (0.24–1.72)

0.58 (0.22–1.55)

0.49 (0.12–1.97)

1.19 (0.75–1.90)

1.07 (0.67–1.69)

0.72 (0.34–1.51)

0.72 (0.34–1.51)

1.29 (0.42–4.04)

0.59 (0.08–4.23)

3.5–5

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

> 5

1.21 (0.84–1.75)

1.18 (0.82–1.70)

1.26 (0.76–2.09)

1.33 (1.06–1.67)

1.26 (1.01–1.59)

1.11 (0.79–1.55)

1.11 (0.79–1.55)

1.57 (0.89–2.79)

0.98 (0.39–2.44)

Combined electrolyte scoring (0–4)

Scoring

Low score (0,1)

1.01 (0.74–1.38)

1.02 (0.75–1.39)

1.04 (0.69–1.57)

1.16 (0.97–1.40)

1.18 (0.98–1.42)

1.06 (0.81–1.39)

1.25 (0.75–2.09)

1.27 (0.76–2.12)

0.65 (0.27–1.57)

Score 2

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

High score (3,4)

1.13 (0.94–1.36)

1.14 (0.95–1.37)

1.13 (0.89–1.42)

1.08 (0.96–1.22)

1.10 (0.98–1.24)

1.06 (0.91–1.25)

0.91 (0.63–1.32)

0.94 (0.65–1.36)

0.84 (0.52–1.37)

  1. aadjusted for age, education, Charslon Comorbidity Index
  2. badjusted for age, education, Charslon Comorbidity Index, creatinine (continuous), interval time, disease severity