Genomic alterations in gastric cancers discovered via whole-exome sequencing

BMC Cancer

Table 4 A detailed overview of DNA copy number gains or losses in primary tumors and metastatic tissues

Unique to the primary tumor tissues
Locating Gene	Locus	V	CN	Locating Gene	Locus	V	CN
ACSL3, PAX3	2q36.1	+	3.49	MAD2L1BP	6p21.1	+	2.69
BRCA1	17q21.31	+	3.79	MSH6, FBXO11	2p16.3	+	3.21
BRCA2, KL	13q13.1	+	2.66	MTCP1	Xq28	+	3.62
CCNB1IP1	14q11.2	+	3.31	MTUS2, FLT1	13q12.3	+	2.66
CCND1	11q13.3	+	5.83	MYB	6q23.3	+	6.07
CDK12	17q12	+	6.5	NCOA4	10q11.23	+	2.93
CDK8	13q12.13	+	2.66	NIN	14q22.1	+	3.44
CDX2, FLT3	13q12.2	+	2.66	NOTCH2	1p11.2	+	4.68
EGFR	7p11.2	+	4.54	NRAS, TRIM33	1p13.2	+	4.68
ELK4, IKBKE, SLC45A3	1q32.1	+	2.74	PDE4DIP	1q21.1	+	7.66
EPCAM, MSH2	2p21	+	3.21	RABEP1, USP6	17p13.2	+	2.82
ERBB2	17q12	+	3.76~ 6.5	RARA, TOP2	17q21.2	+	3.76~ 6.5
ERBB4, IDH1	2q34	+	2.86	RB1	13q14.2	+	2.64
ERCC5	13q33.1	+	2.64	SMAD2	18q21.1	+	3.53
FAM46C, HSD3B2	1p12	+	4.68	STAT3	17q21.2	+	3.79
FEV, ATIC	2q35	+	2.08~ 3.49	SUZ12	17q11.2	+	2.71
FGFR3	4p16.3	+	4.21	TERT	5p15.33	+	3.03
KRT17	17q21.2	+	3.08	TRIM27	6p22.1	+	2.97
KTN1	14q22.3	+	3.44	YWHAE	17p13.3	+	4.21
LCP1	13q14.13	+	2.64	ZMYM2	13q12.11	+	2.66
LRP5	11q13.2	+	5.83	ZRSR2	Xp22.2	+	3.23
Unique to the metastatic tissues
Locating Gene	Locus	V	CN	Locating Gene	Locus	V	CN
CHD6, MAFB, TOP1	20q12	+	3.05	SRC	20q11.23	+	3.05
NUMA1	11q13.4	+	2.94
Common to the primary tumor and metastasis tissues
Locating Gene	Locus	V	CN	Locating Gene	Locus	V	CN
HIP1	7q11.23	+	2.65~ 2.77	RAD51B	14q24.1	+	2.75–2.78
CHIC2, KDR, KIT, PDGFRA	4q12	+	2.67~ 3.17	ETV4	17q21.31	+	2.66–5.11
TMPRSS2	21q22.3	+	2.90~ 3.88	CDKN2A	9p21.3	–	0.8–1.32
PMS2	7p22.1	+	2.62~ 2.78	CDKN2B	9p21.3	–	0.8–1.32

ISSN: 1471-2407