Table 2 The unique mutations in the primary tumor tissue
From: Genomic alterations in gastric cancers discovered via whole-exome sequencing
Sample ID | Gene | Mutation | NM ID | Base changes | AA changes | Domain | VAF | N in Cosmic(tissue) |
|---|---|---|---|---|---|---|---|---|
P2_S | BRAF | frameshift insertion | NM_004333 | c.1208dupC | p.P403fs | – | 0.26 | 1 (Endometrioid carcinoma) |
P2_S | CD276 | nonsynonymous SNV | NM_001024736 | c.C479T | p.T160 M | CD80-like_ immunoglobulin C2-set | 0.149 | – |
P2_S | CUL3 | nonsynonymous SNV | NM_003590 | c.G1091A | p.R364H | Cullin repeat-like-containing domain | 0.102 | 1 (Kidney) |
P2_S | EPHA7 | nonsynonymous SNV | NM_004440 | c.T1056G | p.S352R | Fibronectin type III | 0.11 | – |
P2_S | NKX2–2 | nonsynonymous SNV | NM_002509 | c.C413T | p.A138V | Homeobox domain | 0.163 | 1 (Stomach) |
P3_S | SMAD4 | nonsynonymous SNV | NM_005359 | c.G1082C | p.R361P | SMAD domain_ Dwarfin-type | 0.166 | 1 (Stomach) |
P1_S | STAT6 | nonsynonymous SNV | NM_003153 | c.C1210A | p.Q404K | STAT transcription factor_ DNA-binding | 0.118 | – |