Fig. 3
From: Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer
Inhibition of FGD4 decreased cell proliferation and arrested cells in G2/M phase. Cell proliferation assay showing a significant reduction in proliferation of PC-3 (a) and LNCaP-104S (b) cells transfected with two different FGD4 siRNAs compared to the control siRNAs. Data represent mean ± SD of at least three different experiments run in triplicate. a: * p < 0.0002, B: * p < 0.05, ** p < 0.005. c, d, f and g: Two parameter histogram showing a higher G2/M peak in siRNA transfected PC-3 (d) and LNCaP-104S (g) cells compared to control RNA transfected cells (c and f). e and h: Relative percentage of cells in different cell cycle phases upon inhibition of FGD4 expression in PC-3 (e) and LNCaP-104S (h) cells. Data represent mean ± SD of at least three independent experiments. e: *p < 0.05, *** p < 0.001 H: *p < 0.05, ** p < 0.01, *** p < 0.001).