Table 4 Hazard ratios (95% CI) of colon, rectal and colorectal cancers by changes in physical activity level between enrollment and follow-up (n = 44,498) in the NOWAC Study

Cancer

Models

Consistently active (PA 7–10)

[n = 9417]

Consistently moderately active (PA 5–6)

[n = 13,189]

Increased PA

[n = 7869]

Decreased PA

[n = 6317]

Consistently inactive (PA 1–4)

[n = 7706]

 Colon

Age-adjusted

N of cases: 393

0.83 (0.62–1.11)

69

1.00

134

0.70 (0.51–0.97)

51

0.85 (0.62–1.16)

58

0.91 (0.69–1.20)

81

Multivariable 1

N of cases: 393

0.86 (0.64–1.15)

69

1.00

134

0.69 (0.50–0.96)

51

0.82 (0.60–1.11)

58

0.86 (0.65–1.14)

81

Multivariable 2

N of cases: 393

0.87 (0.65–1.16)

69

1.00

134

0.69 (0.50–0.95)

51

0.81 (0.60–1.11)

58

0.86 (0.65–1.14)

81

 Rectal

Age-adjusted

N of cases: 168

1.57 (1.03–2.41)

43

1.00

42

1.36 (0.86–2.16)

32

1.16 (0.70–1.91)

24

1.02 (0.63–1.66)

27

Multivariable 1

N of cases: 168

1.54 (1.01–2.37)

43

1.00

42

1.34 (0.84–2.12)

32

1.11 (0.67–1.84)

24

1.02 (0.62–1.66)

27

Multivariable 2

N of cases: 168

1.57 (1.02–2.42)

43

1.00

42

1.32 (0.83–2.10)

32

1.11 (0.67–2.84)

24

1.00 (0.61–1.63)

27

 Colorectal

Age-adjusted

N of cases: 561

1.01 (0.80–1.28)

112

1.00

176

0.86 (0.67–1.12)

83

0.92 (0.71–1.20)

82

0.94 (0.74–1.20)

108

Multivariable 1

N of cases: 561

1.03 (0.81–1.31)

112

1.00

176

0.85 (0.65–1.10)

83

0.89 (0.68–1.15)

82

0.90 (0.71–1.15)

108

Multivariable 2

N of cases: 561

1.04 (0.82–1.32)

112

1.00

176

0.84 (0.65–1.10)

83

0.88 (0.68–1.15)

82

0.90 (0.70–1.15)

108