Skip to main content

Table 2 Description of demographic and tumor variables with pairwise comparisons for 11 tumors with germline BAP1 mutations, 43 with BAP1 somatic mutations and 88 with no BAP1 mutations

From: Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma

Variables

BAP1 germline

BAP1 somatic

BAP1 negative

Pairwise comparisons (P-value)

N=11 (0.08) (frequency)

N=43 (0.30) (frequency)

N=88 (0.62) (frequency)

Germline/Somatic

Germline/Negative

Somatic/Negative

Metastases

 Yes N=59 (0.42)

4 (0.36)

32 (0.74)

23 (0.26)

0.03 a

0.72a

<0.001 a

 No N=83 (0.58)

7 (0.64)

11 (0.26)

65 (0.74)

   

Time to metastasis (months) (N=59)

N=4 (0.07)

N=32 (0.54)

N=23 (0.38)

0.07b

0.50b

0.04 c

 Median (19.0 months)

37.5

16.0

26.0

 Mean±SD (26.4±20.9)

35.0±15.8

23±22.5

29.7±19.2

 Range (0-107)

16-49

2-45,90,107d

0-84

Follow-up time (months) in tumors with no metastasis (N=83)

N=7 (0.08)

N=11 (0.13)

N=65 (0.78)

0.59c

0.25c

0.33c

 Median (56.0 months)

24

54.0

58.0

 Mean±SD (59.8±39.0)

43.7±39.3

49.9±30.0

63.2±40.1

 Range (4-191)

4-109

8-90

5-191

Cohort

 1

6 (0.54)

27 (0.63)

57 (0.65)

0.73a

0.74a

0.85a

 2

5 (0.46)

16 (0.37)

31 (0.35)

Source of biopsied sample

 FNA

10 (0.91)

36 (0.84)

73 (0.83)

0.68a

0.69a

1.00a

 Enucleated tumor

1 (0.09)

7 (0.16)

15 (0.17)

BAP1-TPDS personal or family history (N=79 reports)e

 Yes, syndromic tumors present (N=29, 0.37)

8 (1.00)

10 (0.44)

11 (0.23)

0.009 a

<0.001 a

0.10

 No syndromic tumors (N=50, 0.63)

0

13 (0.56)

37 (0.77)

Age (years)

 Median

59.0

61.8

52.2

0.07c

0.86c

0.002 c

 Mean±SD

51.9±13.6

61.2±12.8

53.1±15.0,

 Range

22-67

28-88

14-84

Sex

 Male

7 (0.64)

25 (0.58)

45 (0.51)

1.00a

0.53a

0.46a

 Female

4 (0.36)

18 (0.42)

43 (0.49)

Chromosome 3

 Disomy

1 (0.09)

3 (0.07)

59 (0.67)

1.0a

<0.001 a

<0.001 a

 Monosomy, partial monosomy (N=2), mosaic (N=5)

10 (0.91)

40 (0.93)

26 (0.33)

Tumor diameter (mm)

 Median

14.0

14.0

11.5

0.70c

0.23c

0.003 c

 Mean±SD

13.4±4.4

13.9±3.9

11.7±4.0,

 Range

8.0-20.0

6.0-21.5

5.0-22.0

Tumor thickness (mm)

 Median

6.6

7.0

5.0

0.41c

0.51c

0.002 c

 Mean±SD

6.5±3.6

7.5±3.5

5.6±2.9,

 Range

1.5-12.3

2.0-16.5

1.0-13.1

Ciliary body involvement

 Absent

8 (0.73)

28 (0.65)

74 (0.84)

0.73a

0.40a

0.02 a

 Present

3 (0.27)

15 (0.35)

14 (0.14)

  1. aAssociation test performed using two-tailed Fisher Exact or Chi-square tests
  2. bReported P-values are calculated from a normal approximation of the Mann Whitney test statistic
  3. cTests of means of quantitative variables performed using Mann-Whitney U tests
  4. dThe time for metastasis for 30 of the tumors with somatic mutations was 2-45 months. The time to metastasis for the remaining two tumors was 90 and 107 months
  5. eBAP1-TPDS, BAP1-tumor predisposition syndrome as defined in OMIM #614327 [4] and Pilarski et al [5]
  6. Figures is bold indicate significant P-values <0.05