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Table 1 Demographic and tumor characteristics for 142 UM and assessment of their association with metastasis evaluated by Cox univariate regression for each of the nine variables alone, and multivariate regression that included all variables described in the table

From: Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma

Variables All tumors N=142 (frequency) Univariate regression Multivariate regression
P-value Hazard ratio 95% confidence intervals P-value Hazard ratio 95% confidence intervals
Cohort
 1 90 (0.63)   reference    reference  
 2 52 (0.37) 0.53 0.82 0.44-1.53 0.65 1.18 0.57-2.48
Source of biopsied samplea
 FNA, N=119 (0.84)    reference    reference  
  BAP1 mutation negative 73 (0.61)       
  BAP1 mutation positive 46 (0.39)       
 Enucleated tumor, N= 23 (0.16)   0.01 2.12 1.19-3.76 0.08 2.04 0.92-4.52
  BAP1 mutation negative 15 (0.65)       
  BAP1 mutation positive 8 (0.35)       
Age (years)   0.04 1.02 1.00-1.04 0.03 1.02 1.00-1.05
 Median 56.7       
 Mean±SD 55.4±14.7       
 Range 14-88       
Sex
 Male 77 (0.54)   reference    reference  
 Female 65 (0.46) 0.24 0.73 0.43-1.24 0.73 0.90 0.50-1.63
Chromosome 3        
 Disomy 63 (0.44)   reference    reference  
 Monosomy, partial monosomy (N=2), mosaic (N=5) 79 (0.56) <0.001 4.64 2.46-8.78 0.008 2.99 1.33-6.72
Tumor diameter (mm)   <0.001 1.25 1.17-1.35 <0.001 1.20 1.10-1.31
 Median 12.0       
 Mean±SD 12.5±4.1       
 Range 5.0-22.0       
Tumor thickness (mm)   <0.001 1.22 1.13-1.31 0.61 0.97 0.87-1.09
 Median 5.7       
 Mean±SD 6.2±3.3,       
 Range 1.0-16.5       
Ciliary body involvement
 Absent 110 (0.78) <0.001 reference    reference  
 Present 32 (0.22) 3.05 1.79-5.20 0.15 1.54 0.85-2.80
BAP1
 Negative 88 (0.62)   reference    reference  
 Somatic 43 (0.30) <0.001 4.81 2.79-8.28 0.02 2.20 1.13-4.30
 Germline 11 (0.08) 0.33 1.70 0.59-4.91 0.81 0.87 0.28-2.72
  1. aThere was no significant difference in the number of BAP1 mutation negative tumors and those carrying germline or somatic mutations UM biopsies from FNA samples compared to enucleated tumors (P=0.79, Fisher Exact test)
  2. Figures is bold indicate significant P-values <0.05