Table 1 Demographic and tumor characteristics for 142 UM and assessment of their association with metastasis evaluated by Cox univariate regression for each of the nine variables alone, and multivariate regression that included all variables described in the table

 1

90 (0.63)

reference

reference

 2

52 (0.37)

0.53

0.82

0.44-1.53

0.65

1.18

0.57-2.48

 FNA, N=119 (0.84)

reference

reference

  BAP1 mutation negative

73 (0.61)

  BAP1 mutation positive

46 (0.39)

 Enucleated tumor, N= 23 (0.16)

0.01

2.12

1.19-3.76

0.08

2.04

0.92-4.52

  BAP1 mutation negative

15 (0.65)

  BAP1 mutation positive

8 (0.35)

Age (years)

0.04

1.02

1.00-1.04

0.03

1.02

1.00-1.05

 Median

56.7

 Mean±SD

55.4±14.7

 Range

14-88

 Male

77 (0.54)

reference

reference

 Female

65 (0.46)

0.24

0.73

0.43-1.24

0.73

0.90

0.50-1.63

Chromosome 3

 Disomy

63 (0.44)

reference

reference

 Monosomy, partial monosomy (N=2), mosaic (N=5)

79 (0.56)

<0.001

4.64

2.46-8.78

0.008

2.99

1.33-6.72

Tumor diameter (mm)

<0.001

1.25

1.17-1.35

<0.001

1.20

1.10-1.31

 Median

12.0

 Mean±SD

12.5±4.1

 Range

5.0-22.0

Tumor thickness (mm)

<0.001

1.22

1.13-1.31

0.61

0.97

0.87-1.09

 Median

5.7

 Mean±SD

6.2±3.3,

 Range

1.0-16.5

 Absent

110 (0.78)

<0.001

reference

reference

 Present

32 (0.22)

3.05

1.79-5.20

0.15

1.54

0.85-2.80

 Negative

88 (0.62)

reference

reference

 Somatic

43 (0.30)

<0.001

4.81

2.79-8.28

0.02

2.20

1.13-4.30

 Germline

11 (0.08)

0.33

1.70

0.59-4.91

0.81

0.87

0.28-2.72