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Table 1 Interactions Detected by Protocol Guidance and Lexicomp® Including Their Mechanism of Interaction and Clinical Relevance

From: Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials

Study Agent(s) Interacting Drug (n with interaction) Protocol Guidance Lexicomp® Clinically Relevanta Interaction Mechanism
everolimus carvedilol (2) Avoid yes yes P-gp
dasatinib antacids (1) Avoid yes yes pH
vemurafenib ondansetron (1) Avoid yes yes QT
dabrafenib amlodipine (2) Avoid yes no CYP450
vemurafenib venlafaxine (1) Avoid yes no QT
cabozantinib ondansetron (1) Avoid no no QT
ipilimumab, nivolumab ondansetron (2) Avoid no no QT
dabrafenib omeprazoleb (1) Caution yes no pH
dabrafenib atorvastatin (1) Caution yes no CYP450
dabrafenib omeprazolec (1) Caution yes no CYP450
olaparib cetirizine (1) Caution no no P-gp
olaparib ranitidine (1) Caution no no P-gp
testosterone dabigatran (1) Caution no no anticoagulation
trametinib duloxetine (1) Caution no no protein binding
trametinib olanzapine (1) Caution no no protein binding
enzalutamide amlodipine (2) None yes yes CYP450
enzalutamide citalopram (1) None yes yes CYP450
enzalutamide diltiazem (1) None yes yes CYP450
enzalutamide omeprazole (1) None yes yes CYP450
enzalutamide tramadol (2) None yes yes CYP450
enzalutamide venlafaxine (1) None yes yes CYP450
crizotinib escitalopram (1) None yes yes QT
dabrafenib tamsulosin (1) None yes no CYP450
enzalutamide alprazolam (1) None yes no CYP450
enzalutamide hydrocodone (1) None yes no CYP450
enzalutamide modafinil (1) None yes no CYP450
enzalutamide ondansetron (2) None yes no CYP450
enzalutamide tamsulosin (1) None yes no CYP450
dexamethasone echinacea (1) None yes no immunosuppression
pomalidomide echinacea (1) None yes no immunosuppression
pomalidomide hydrocodone (3) None yes no CNS depression
pomalidomide oxycodone (2) None yes no CNS depression
pomalidomide tramadol (4) None yes no CNS depression
crizotinib granisetron (1) None yes no QT
vemurafenib albuterol (1) None yes no QT
dexamethasone antacids (3) None yes no unknown
  1. P-gp P-glycoprotein
  2. aClinical relevance was determined by study team review and defined as a drug-drug interaction that would require a medication change to ensure study agent safety/efficacy at enrollment
  3. bdabrafenib as victim and omeprazole as perpetrator
  4. comeprazole as victim and dabrafenib as perpetrator