Table 1 Interactions Detected by Protocol Guidance and Lexicomp® Including Their Mechanism of Interaction and Clinical Relevance
Study Agent(s) | Interacting Drug (n with interaction) | Protocol Guidance | Lexicomp® | Clinically Relevanta | Interaction Mechanism |
|---|---|---|---|---|---|
everolimus | carvedilol (2) | Avoid | yes | yes | P-gp |
dasatinib | antacids (1) | Avoid | yes | yes | pH |
vemurafenib | ondansetron (1) | Avoid | yes | yes | QT |
dabrafenib | amlodipine (2) | Avoid | yes | no | CYP450 |
vemurafenib | venlafaxine (1) | Avoid | yes | no | QT |
cabozantinib | ondansetron (1) | Avoid | no | no | QT |
ipilimumab, nivolumab | ondansetron (2) | Avoid | no | no | QT |
dabrafenib | omeprazoleb (1) | Caution | yes | no | pH |
dabrafenib | atorvastatin (1) | Caution | yes | no | CYP450 |
dabrafenib | omeprazolec (1) | Caution | yes | no | CYP450 |
olaparib | cetirizine (1) | Caution | no | no | P-gp |
olaparib | ranitidine (1) | Caution | no | no | P-gp |
testosterone | dabigatran (1) | Caution | no | no | anticoagulation |
trametinib | duloxetine (1) | Caution | no | no | protein binding |
trametinib | olanzapine (1) | Caution | no | no | protein binding |
enzalutamide | amlodipine (2) | None | yes | yes | CYP450 |
enzalutamide | citalopram (1) | None | yes | yes | CYP450 |
enzalutamide | diltiazem (1) | None | yes | yes | CYP450 |
enzalutamide | omeprazole (1) | None | yes | yes | CYP450 |
enzalutamide | tramadol (2) | None | yes | yes | CYP450 |
enzalutamide | venlafaxine (1) | None | yes | yes | CYP450 |
crizotinib | escitalopram (1) | None | yes | yes | QT |
dabrafenib | tamsulosin (1) | None | yes | no | CYP450 |
enzalutamide | alprazolam (1) | None | yes | no | CYP450 |
enzalutamide | hydrocodone (1) | None | yes | no | CYP450 |
enzalutamide | modafinil (1) | None | yes | no | CYP450 |
enzalutamide | ondansetron (2) | None | yes | no | CYP450 |
enzalutamide | tamsulosin (1) | None | yes | no | CYP450 |
dexamethasone | echinacea (1) | None | yes | no | immunosuppression |
pomalidomide | echinacea (1) | None | yes | no | immunosuppression |
pomalidomide | hydrocodone (3) | None | yes | no | CNS depression |
pomalidomide | oxycodone (2) | None | yes | no | CNS depression |
pomalidomide | tramadol (4) | None | yes | no | CNS depression |
crizotinib | granisetron (1) | None | yes | no | QT |
vemurafenib | albuterol (1) | None | yes | no | QT |
dexamethasone | antacids (3) | None | yes | no | unknown |