Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study

Table 4 HRs^a and 95% CIs of all-cause mortality per 10-point-increments of QLQ-C30 scales in CRC survivors (n = 1294)

	Age- & sex-adjusted HR (95% CI)	Multivariable-adjusted^b HR (95% CI)
Summary score^c	0.76 (0.70–0.82)	0.76 (0.70–0.82)
Global QOL^c	0.80 (0.75–0.85)	0.80 (0.75–0.86)
Functioning Scales^c
Physical Functioning	0.78 (0.74–0.83)	0.80 (0.75–0.86)
Role Functioning	0.86 (0.82–0.90)	0.87 (0.83–0.91)
Emotional Functioning	0.89 (0.84–0.94)	0.88 (0.83–0.94)
Social Functioning	0.86 (0.82–0.90)	0.87 (0.83–0.91)
Cognitive Functioning	0.94 (0.88–1.01)	0.95 (0.88–1.02)
Symptom Scales^d
Pain	1.11 (1.06–1.16)	1.10 (1.05–1.16)
Nausea/Vomiting	1.31 (1.21–1.43)	1.31 (1.19–1.43)
Fatigue	1.21 (1.14–1.27)	1.19 (1.13–1.26)
Insomnia	1.08 (1.04–1.13)	1.08 (1.03–1.13)
Dyspnea	1.14 (1.09–1.19)	1.13 (1.08–1.19)
Appetite Loss	1.19 (1.12–1.27)	1.18 (1.11–1.26)
Constipation	1.08 (1.02–1.14)	1.09 (1.03–1.15)
Diarrhea	1.02 (0.97–1.08)	1.03 (0.97–1.09)
Financial Difficulties	1.09 (1.03–1.15)	1.07 (1.01–1.14)

Abbreviations: BMI Body mass index, CI Confidence interval, CRC Colorectal cancer, HR Hazard ratio, QLQ-C30 Quality of life questionnaire core 30, QOL Quality of life
Values were calculated for a 10-point-increment in scales
^aCalculated with Cox proportional hazards regression model
^bAdjusted for sex, age at HRQOL assessment, BMI, physical activity, tumor location, type of therapy, metastases, other cancer, current stoma, education, family status, smoking status, and (age x time)
^cHigher scores of the summary score, the global QOL, and the functioning scales indicate a higher HRQOL or a higher functioning
^dHigher scores of the symptom scales indicate a higher extent of symptoms

ISSN: 1471-2407