Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis

Table 4 Univariate analysis for possible factors resulted in amputation

Variable	Amputation (N = 18)	Limb Salvage (N = 66)	P Value^*
Mean time between symptom appeared to diagnosis (mo)	2.89 ± 1.83	2.96 ± 2.63	0.947
Tumor volumes (cm³)	131.06 ± 86.46	96.70 ± 75.21	0.343
Extraosseous Tumor Volumes (cm³)	83.57 ± 78.75	39.09 ± 34.65	0.144
Nearest to popliteal vessels (mean; cm)
Reactive zone	0.05 ± 0.15	0.31 ± 0.39	0.052
Tumor	0.45 ± 0.51	1.33 ± 0.90	0.016
Nearest to anterior tibial vessels (mean; cm)
Reactive zone	0.00 ± 0.00	0.11 ± 0.27	0.192
Tumor	0.08 ± 0.25	0.62 ± 0.65	0.020
Nearest to posterior tibial vessels (mean; cm)
Reactive zone	0.00 ± 0.00	0.36 ± 0.38	0.008
Tumor	0.41 ± 0.56	1.35 ± 0.84	0.010

*The p value was calculated using the Fisher’s exact test for categorical variables and t-test for continuous variables

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