Fig. 6From: Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinomaEffect of PPAR agonists on the cell invasion and migration phenotype of ALDH7A1-depleted cells. a-c Quantification of wound healing assays after 24āh migration. aĀ Primary BJ cells, HUH7 and cĀ CAKI2 cancer cells were treated with PPARĪ± agonist or DMSO as a control. The migrated distance was measured (Ī¼m), and averages from three independently transduced cell lines were calculated (Ā± SEM). d Quantification of cell invasion of primary BJ cellsĀ through Matrigel over 24āh. The bar plots show the percent of cells that crossed the gel barrier (average of 3 independent experiments Ā± SEM). The two-tailed Mann Whitney test was used to calculate p-valuesBack to article page