Fig. 2

ALDH7A1 mRNA levels in liver (LIHC) and kidney (KIRC) cancer. a, b ALDH7A1 mRNA levels in normal (control) and tumor tissue from the LIHC and KIRC TCGA datasets. RSEM (RNA-seq expectation by maximization) reads are plotted on the Y-axis. P-values were calculated with the Mann–Whitney U test. c, d Kaplan-Meier plots showing overall survival of LIHC and KIRC patients as a function of ALDH7A1 mRNA expression. Patients were divided into three equal groups based on ALDH7A1 mRNA expression levels. Blue = lower 1/3; Black = middle 1/3; red = top 1/3. P-values were determined by Cox proportion hazard regression models. e-h ALDH7A1 mRNA levels as a function of tumor stage (e, f) and grade (g, h) for LIHC and KIRC patients. The two-tailed Mann Whitney test was used to calculate p-values. i, j Kaplan-Meier plots showing overall survival of LIHC and KIRC patients as a function of ALDH7A1 mRNA expression and stage. Patients were divided into early (stage I and II) and late (stage III and IV) stage groups. Each group was divided into two subgroups based on ALDH7A1 expression (at median). Significance was determined using the likelihood ratio test