Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma

Table 4 Univariate analysis of potential prognostic factors

Items	3-yr LRFS		3-yr DMFS		3-yr OS
	%	p	%	p	%	p
Gender
Male	90.1	0.356	89.3	0.387	41.8	0.980
Female	83.1	0.356	91.8	0.387	47.6	0.980
Age (years)
< 60	84.9	0.884	89.0	0.070	51.0	0.026
≥ 60	87.2	0.884	100	0.070	32.4	0.026
rT stage
rT1–2	96.6	0.070	94.7	0.362	51.8	0.241
rT3–4	77.9	0.070	88.8	0.362	42.9	0.241
FD (Gy)
≤ 2	81.6	0.298	90.3	0.820	45.5	0.645
> 2	94.0	0.298	93.2	0.820	47.4	0.645
Use of Chem
No	88.8	0.433	83.2	0.328	49.0	0.196
Yes	83.8	0.433	93.9	0.328	45.1	0.196
TTR (years)
≤ 2	91.7	0.248	83.9	0.035	43.6	0.977
> 2	82.1	0.248	94.8	0.035	47.0	0.977
IMRT dose (Gy)
< 70	85.6	0.790	93.6	0.908	42.8	0.652
≥ 70	84.7	0.790	86.1	0.908	54.0	0.652
Cumulative dose(Gy)
< 140	85.5	0.508	88.3	0.118	49.2	0.095
≥ 140	88.0		96.2		41.0
Brachytherapy
No	79.1	0.027	90.6	0.887	44.6	0.495
Yes	100		94.4		57.9

Abbreviations: LRFS, local recurrence–free survival; DMFS, distant metastases–free survival; OS, overall survival; FD, Fractional dose; Chem, chemotherapy; TTR, time to recurrence

ISSN: 1471-2407