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Fig. 5 | BMC Cancer

Fig. 5

From: TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90α/uPA/MMP2 signaling pathway

Fig. 5

TRPM7 inhibitor, Waixenicin A suppresses the CSC phenotype of lung cancer cells. a Chemical structure of Waixenicin A with molecular formular C26H36O7 and molecular weight 460.56 mg/mol. b The inhibitory effect of 5 μM and 10 μM Waixenicin A on the expression levels of TRPM7, Vimentin, Survivin, STAT3, HSP90α, uPA, and MMP2 in 95D cells. c Photo image and (d) histography showing significantly inhibited tumorsphere formation by shTRPM7 and/or Waixenicin A treatment

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