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Fig. 3 | BMC Cancer

Fig. 3

From: TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90α/uPA/MMP2 signaling pathway

Fig. 3

Downregulation of TRPM7 expression suppress the viability and metastatic phenotype of human lung cancer cells. a The effect of shTRPM7 clones 1 and 2 on the mRNA expression levels of TRPM7, Vimentin, E-cadherin, p21 and BAK. b Fewer colonies were formed by the shTRPM7 clones compared to the control A549 and 95D cells. c Cell viability of A549 and 95D cells is significantly reduced in shTRPM7 clones, compared to the control cells. d shTRPM7 clones exhibited suppressed migration and invasion potential, in comparison to the control A549 and 95D cells. GAPDH served as loading control. * p < 0.05, ** p < 0.01, *** p < 0.001

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