| |
General survival
|
Disease-free survival
|
|---|
|
Univariate
|
Multivariate
|
Univariate
|
Multivariate
|
|---|
|
HR
|
95% CI
|
p
|
HR
|
95% CI
|
p
|
HR
|
95% CI
|
p
|
HR
|
95% CI
|
p
|
|---|
|
Age
|
1.06
|
1.04–1.07
|
< 0.001
|
1.05
|
1.03–1.07
|
< 0.001
|
1
|
0.99–1.02
|
0.62
| | | |
|
Gender
|
|
Male
|
1.08
|
0.76-1.52
|
0.67
| | | |
1.01
|
0.69–1.46
|
0.99
| | | |
|
Female
|
1
| | | | | |
1
| | | | | |
|
Location
|
|
Right colon
|
1.95
|
0.94–4.03
|
0.186
| | | |
1.07
|
0.45–2.57
|
0.41
| | | |
|
Transverse colon
|
1.74
|
0.78–3.90
| | | | |
0.81
|
0.28–2.34
| | | | |
|
Left colon
|
1.12
|
0.46–2.74
| | | | |
0.37
|
0.09–1.49
| | | | |
|
Sigmoid colon
|
1.89
|
0.82–3.89
| | | | |
1.13
|
0.48–2.66
| | | | |
|
Unknown
|
1
| | | | | |
1
| | | | | |
|
Histology
|
|
Adenocarcinoma
|
0.43
|
0.19–0.98
|
0.12
| | | |
0.30
|
0.11–0.81
|
0.30
| | | |
|
Mucinous Variant
|
0.41
|
0.17–0.99
| | | | |
0.28
|
0.09–0.85
| | | | |
|
Signet-ring cell
|
1
| | | | | |
1
| | | | | |
|
Grade
|
|
Unknown
|
1.39
|
0.54–3.59
|
0.22
| | | |
1.04
|
0.31–3.45
|
0.68
| | | |
|
Good
|
1.11
|
0.58–2.13
| | | | |
0.70
|
0.31–1.55
| | | | |
|
Moderate
|
1.49
|
0.81–2.76
| | | | |
0.98
|
0.47–2.03
| | | | |
|
Poor
|
1
| | | | | |
1
| | | | | |
|
Major Size (mm)
|
1
|
0.99–1.01
|
0.96
| | | |
1
|
0.99–1.01
|
0.399
| | | |
|
Number retrieved LN
|
0.97
|
0.95–0.99
|
0.007
|
1.07
|
0.99–1.15
|
0.045
|
0.99
|
0.97–1.02
|
0.99
| | | |
|
Less than 12
|
1.38
|
1.05–1.82
|
0.023
| | | |
0.90
|
0.62–1.31
|
0.87
| | | |
|
12 or more
|
1
| | | | | |
1
| | | | | |
|
Number positive LN
|
1.09
|
1.05–1.13
|
< 0.001
|
1.97
|
1.94–1.99
|
0.027
|
1.02
|
1.01–1.02
|
< 0.0001
|
1.08
|
1.01–1.15
|
0.02
|
|
Lymph Node Ratio (LNR)
|
1.01
|
1–1.02
|
< 0.001
| | | |
1.02
|
1.01–1.03
|
< 0.0001
| | | |
|
0–24%
|
0.32
|
0.19–0.54
|
< 0.001
| | | |
0.20
|
0.10–0.38
|
< 0.0001
| | | |
|
25–60%
|
0.60
|
0.34–1.09
| | | | |
0.46
|
0.22–0.97
| | | | |
|
> 60%
|
1
| | | | | |
1
| | | | | |
|
Condensed pT (6th Ed.)
|
|
pT1–2
|
0.48
|
0.33–0.72
|
< 0.001
|
0.46
|
0.31–0.70
|
< 0.001
|
2.60
|
1.43–4.73
|
< 0.0001
|
2.27
|
1.24–4.15
|
0.008
|
|
pT3–4
|
1
| | | | | |
1
| | | | | |
|
Condensed pN (7th Ed.)
|
|
pN0
|
0.47
|
0.33–0.69
|
< 0.001
| | | |
0.25
|
0.16–0.40
|
< 0.0001
| | | |
|
pN1
|
0.65
|
0.43–0.98
| | | | |
0.34
|
0.20–0.58
| | | | |
|
pN2
|
1
| | | | | |
1
| | | | | |
|
Condensed TNM stage
|
|
I
|
0.31
|
0.19–0.52
|
< 0.001
| | | |
0.21
|
0.10–0.47
|
< 0.0001
| | | |
|
II
|
0.78
|
0.59–1.03
| | | | |
0.63
|
0.42–0.93
| | | | |
|
III
|
1
| | | | | |
1
| | | | | |
|
LODDS
|
1.30
|
1.18–1.43
|
< 0.001
|
1.43
|
1.11–1.85
|
0.006
|
1.41
|
1.24–1.61
|
< 0.0001
|
1.21
|
1.01–1.46
|
0.036
|
|
LODDS1 (≤ −2)
|
0.28
|
0.14–0.55
|
< 0.001
| | | |
0.20
|
0.08–0.51
|
0.005
| | | |
|
LODDS2 (> −2 to ≤1)
|
0.46
|
0.23–0.91
| | | | |
0.39
|
0.15–0.98
| | | | |
|
LODDS3 (> 1)
|
1
| | | | | |
1
| | | | | |
|
Adjuvant Chemotherapy
|
|
Yes
|
0.63
|
0.46–0.85
|
0.003
| | | |
1.93
|
1.33–2.81
|
< 0.0001
| | | |
|
No
|
1
| | | | | |
1
| | | | | |
- LN Lymph nodes. Multivariate study: variables in continuous format
