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Table 2 General survival and disease-free survival: univariate and multivariate analysis

From: The lymph node status as a prognostic factor in colon cancer: comparative population study of classifications using the logarithm of the ratio between metastatic and nonmetastatic nodes (LODDS) versus the pN-TNM classification and ganglion ratio systems

  General survival Disease-free survival
Univariate Multivariate Univariate Multivariate
HR 95% CI p HR 95% CI p HR 95% CI p HR 95% CI p
Age 1.06 1.04–1.07 <  0.001 1.05 1.03–1.07 <  0.001 1 0.99–1.02 0.62    
Gender
 Male 1.08 0.76-1.52 0.67     1.01 0.69–1.46 0.99    
 Female 1       1      
Location
 Right colon 1.95 0.94–4.03 0.186     1.07 0.45–2.57 0.41    
 Transverse colon 1.74 0.78–3.90      0.81 0.28–2.34     
 Left colon 1.12 0.46–2.74      0.37 0.09–1.49     
 Sigmoid colon 1.89 0.82–3.89      1.13 0.48–2.66     
 Unknown 1       1      
Histology
Adenocarcinoma 0.43 0.19–0.98 0.12     0.30 0.11–0.81 0.30    
 Mucinous Variant 0.41 0.17–0.99      0.28 0.09–0.85     
 Signet-ring cell 1       1      
Grade
 Unknown 1.39 0.54–3.59 0.22     1.04 0.31–3.45 0.68    
 Good 1.11 0.58–2.13      0.70 0.31–1.55     
 Moderate 1.49 0.81–2.76      0.98 0.47–2.03     
 Poor 1       1      
Major Size (mm) 1 0.99–1.01 0.96     1 0.99–1.01 0.399    
Number retrieved LN 0.97 0.95–0.99 0.007 1.07 0.99–1.15 0.045 0.99 0.97–1.02 0.99    
 Less than 12 1.38 1.05–1.82 0.023     0.90 0.62–1.31 0.87    
 12 or more 1       1      
Number positive LN 1.09 1.05–1.13 <  0.001 1.97 1.94–1.99 0.027 1.02 1.01–1.02 <  0.0001 1.08 1.01–1.15 0.02
Lymph Node Ratio (LNR) 1.01 1–1.02 <  0.001     1.02 1.01–1.03 <  0.0001    
 0–24% 0.32 0.19–0.54 <  0.001     0.20 0.10–0.38 <  0.0001    
 25–60% 0.60 0.34–1.09      0.46 0.22–0.97     
  > 60% 1       1      
Condensed pT (6th Ed.)
 pT1–2 0.48 0.33–0.72 <  0.001 0.46 0.31–0.70 <  0.001 2.60 1.43–4.73 <  0.0001 2.27 1.24–4.15 0.008
 pT3–4 1       1      
Condensed pN (7th Ed.)
 pN0 0.47 0.33–0.69 <  0.001     0.25 0.16–0.40 <  0.0001    
 pN1 0.65 0.43–0.98      0.34 0.20–0.58     
 pN2 1       1      
Condensed TNM stage
 I 0.31 0.19–0.52 <  0.001     0.21 0.10–0.47 <  0.0001    
 II 0.78 0.59–1.03      0.63 0.42–0.93     
 III 1       1      
LODDS 1.30 1.18–1.43 < 0.001 1.43 1.11–1.85 0.006 1.41 1.24–1.61 <  0.0001 1.21 1.01–1.46 0.036
 LODDS1 (≤ −2) 0.28 0.14–0.55 <  0.001     0.20 0.08–0.51 0.005    
 LODDS2 (> −2 to ≤1) 0.46 0.23–0.91      0.39 0.15–0.98     
 LODDS3 (>  1) 1       1      
Adjuvant Chemotherapy
 Yes 0.63 0.46–0.85 0.003     1.93 1.33–2.81 < 0.0001    
 No 1       1      
  1. LN Lymph nodes. Multivariate study: variables in continuous format
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