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Table 2 General survival and disease-free survival: univariate and multivariate analysis

From: The lymph node status as a prognostic factor in colon cancer: comparative population study of classifications using the logarithm of the ratio between metastatic and nonmetastatic nodes (LODDS) versus the pN-TNM classification and ganglion ratio systems

 

General survival

Disease-free survival

Univariate

Multivariate

Univariate

Multivariate

HR

95% CI

p

HR

95% CI

p

HR

95% CI

p

HR

95% CI

p

Age

1.06

1.04–1.07

<  0.001

1.05

1.03–1.07

<  0.001

1

0.99–1.02

0.62

   

Gender

 Male

1.08

0.76-1.52

0.67

   

1.01

0.69–1.46

0.99

   

 Female

1

     

1

     

Location

 Right colon

1.95

0.94–4.03

0.186

   

1.07

0.45–2.57

0.41

   

 Transverse colon

1.74

0.78–3.90

    

0.81

0.28–2.34

    

 Left colon

1.12

0.46–2.74

    

0.37

0.09–1.49

    

 Sigmoid colon

1.89

0.82–3.89

    

1.13

0.48–2.66

    

 Unknown

1

     

1

     

Histology

Adenocarcinoma

0.43

0.19–0.98

0.12

   

0.30

0.11–0.81

0.30

   

 Mucinous Variant

0.41

0.17–0.99

    

0.28

0.09–0.85

    

 Signet-ring cell

1

     

1

     

Grade

 Unknown

1.39

0.54–3.59

0.22

   

1.04

0.31–3.45

0.68

   

 Good

1.11

0.58–2.13

    

0.70

0.31–1.55

    

 Moderate

1.49

0.81–2.76

    

0.98

0.47–2.03

    

 Poor

1

     

1

     

Major Size (mm)

1

0.99–1.01

0.96

   

1

0.99–1.01

0.399

   

Number retrieved LN

0.97

0.95–0.99

0.007

1.07

0.99–1.15

0.045

0.99

0.97–1.02

0.99

   

 Less than 12

1.38

1.05–1.82

0.023

   

0.90

0.62–1.31

0.87

   

 12 or more

1

     

1

     

Number positive LN

1.09

1.05–1.13

<  0.001

1.97

1.94–1.99

0.027

1.02

1.01–1.02

<  0.0001

1.08

1.01–1.15

0.02

Lymph Node Ratio (LNR)

1.01

1–1.02

<  0.001

   

1.02

1.01–1.03

<  0.0001

   

 0–24%

0.32

0.19–0.54

<  0.001

   

0.20

0.10–0.38

<  0.0001

   

 25–60%

0.60

0.34–1.09

    

0.46

0.22–0.97

    

  > 60%

1

     

1

     

Condensed pT (6th Ed.)

 pT1–2

0.48

0.33–0.72

<  0.001

0.46

0.31–0.70

<  0.001

2.60

1.43–4.73

<  0.0001

2.27

1.24–4.15

0.008

 pT3–4

1

     

1

     

Condensed pN (7th Ed.)

 pN0

0.47

0.33–0.69

<  0.001

   

0.25

0.16–0.40

<  0.0001

   

 pN1

0.65

0.43–0.98

    

0.34

0.20–0.58

    

 pN2

1

     

1

     

Condensed TNM stage

 I

0.31

0.19–0.52

<  0.001

   

0.21

0.10–0.47

<  0.0001

   

 II

0.78

0.59–1.03

    

0.63

0.42–0.93

    

 III

1

     

1

     

LODDS

1.30

1.18–1.43

< 0.001

1.43

1.11–1.85

0.006

1.41

1.24–1.61

<  0.0001

1.21

1.01–1.46

0.036

 LODDS1 (≤ −2)

0.28

0.14–0.55

<  0.001

   

0.20

0.08–0.51

0.005

   

 LODDS2 (> −2 to ≤1)

0.46

0.23–0.91

    

0.39

0.15–0.98

    

 LODDS3 (>  1)

1

     

1

     

Adjuvant Chemotherapy

 Yes

0.63

0.46–0.85

0.003

   

1.93

1.33–2.81

< 0.0001

   

 No

1

     

1

     
  1. LN Lymph nodes. Multivariate study: variables in continuous format