Fig. 1
From: Harnessing soft tissue sarcoma with low-dose pazopanib – a matter of blood levels
Calculated pazopanib trough levels. a: For patient A, pazopanib dose was rapidly reduced to 200 mg QD in the first three weeks and further reduced to 200 mg every other day in week 28. Corresponding doses of pazopanib were: week 0–1 800 mg QD, week 1–2 stop, week 2–2.5 600 mg QD, week 2.5–3 stop, week 3–11.5 200 mg QD, week 11.5–13 stop, week 13–28 200 mg QD, week 28–59 200 mg every other day. b: For patient B, pazopanib dose was reduced to 400 mg QD after two months and to 200 mg QD 1-week-on, 1-week-off after three months. Corresponding doses of pazopanib were: week 0–6 800 mg QD, week 6–8 stop, week 8–12 400 mg QD, week 12–13 stop, week 13–39 200 mg QD 1-week-on, 1-week-off. The dashed line indicates the pharmacokinetic target of Cmin ≥ 20.5 mg/L. The arrows indicate the times at which doses were changed. Cmin = minimum blood concentration, QAD = every other day, QD = once daily