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Table 6 Multivariate Cox models among factors which might affect the recurrence, the disease free survival (DFS), the 5-year survival and the overall survival (OS) in stage II patients

From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients

 

Recurrence

DFS

5-year survival

Overall Survival

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

NLR

  ≤ 4.7

1

  

1

  

1

  

1

  

  > 4.7

1.68

0.37–7.71

0.506

2.76

1.07–7.13

0.036

3.84

1.39–10.63

0.01

3.62

1.33–9.82

0.012

Gender

 Female

1

  

1

  

1

  

1

  

 Male

1.44

0.44–4.71

0.546

1.32

0.63–2.77

0.464

1.02

0.44–2.37

0.961

1.09

0.48–2.50

0.838

Age

  ≤ 72

1

  

1

  

1

  

1

  

  > 72

0.88

0.30–2.57

0.811

1.64

0.79–3.41

0.183

2.33

0.94–5.75

0.066

2.56

1.05–6.26

0.039

Primary tumor

 Right colon

1

  

1

  

1

  

1

  

 Left colon

0.96

0.21–4.40

0.958

0.88

0.33–2.35

0.794

0.95

0.31–2.94

0.935

0.96

0.31–2.95

0.947

 Rectum

1.98

0.53–7.41

0.312

1.75

0.70–4.39

0.233

1.59

0.53–4.76

0.41

1.74

0.59–5.11

0.317

Grade

 Low

1

  

1

  

1

  

1

  

 Medium + High

1.67

0.37–7.58

0.506

1.34

0.53–3.40

0.541

1.31

0.45–3.80

0.625

1.36

0.47–3.93

0.569

No lymph nodes yield

  ≥ 12

   

1

  

1

  

1

  

  < 12

   

1.82

0.66–5.07

0.249

2.76

0.90–8.45

0.075

2.4

0.80–7.19

0.117

Perineural invasion

 No

   

1

  

1

     

 Yes

   

0.49

0.08–2.85

0.426

0.57

0.09–3.78

0.562

0.63

0.10–4.04

0.624

Vascular invasion

 No

1

  

1

  

1

  

1

  

 Yes

2.65

0.53–13.18

0.234

2.09

0.71–6.13

0.182

2.28

0.66–7.89

0.192

2.22

0.65–7.58

0.205

Lymphatic invasion

 No

1

  

1

  

1

  

1

  

 Yes

0.93

0.10–8.70

0.953

2.3

0.75–7.02

0.145

2.06

0.55–7.69

0.284

2.12

0.58–7.80

0.257