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Table 6 Multivariate Cox models among factors which might affect the recurrence, the disease free survival (DFS), the 5-year survival and the overall survival (OS) in stage II patients

From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients

  Recurrence DFS 5-year survival Overall Survival
HR 95% CI p value HR 95% CI p value HR 95% CI p value HR 95% CI p value
NLR
  ≤ 4.7 1    1    1    1   
  > 4.7 1.68 0.37–7.71 0.506 2.76 1.07–7.13 0.036 3.84 1.39–10.63 0.01 3.62 1.33–9.82 0.012
Gender
 Female 1    1    1    1   
 Male 1.44 0.44–4.71 0.546 1.32 0.63–2.77 0.464 1.02 0.44–2.37 0.961 1.09 0.48–2.50 0.838
Age
  ≤ 72 1    1    1    1   
  > 72 0.88 0.30–2.57 0.811 1.64 0.79–3.41 0.183 2.33 0.94–5.75 0.066 2.56 1.05–6.26 0.039
Primary tumor
 Right colon 1    1    1    1   
 Left colon 0.96 0.21–4.40 0.958 0.88 0.33–2.35 0.794 0.95 0.31–2.94 0.935 0.96 0.31–2.95 0.947
 Rectum 1.98 0.53–7.41 0.312 1.75 0.70–4.39 0.233 1.59 0.53–4.76 0.41 1.74 0.59–5.11 0.317
Grade
 Low 1    1    1    1   
 Medium + High 1.67 0.37–7.58 0.506 1.34 0.53–3.40 0.541 1.31 0.45–3.80 0.625 1.36 0.47–3.93 0.569
No lymph nodes yield
  ≥ 12     1    1    1   
  < 12     1.82 0.66–5.07 0.249 2.76 0.90–8.45 0.075 2.4 0.80–7.19 0.117
Perineural invasion
 No     1    1      
 Yes     0.49 0.08–2.85 0.426 0.57 0.09–3.78 0.562 0.63 0.10–4.04 0.624
Vascular invasion
 No 1    1    1    1   
 Yes 2.65 0.53–13.18 0.234 2.09 0.71–6.13 0.182 2.28 0.66–7.89 0.192 2.22 0.65–7.58 0.205
Lymphatic invasion
 No 1    1    1    1   
 Yes 0.93 0.10–8.70 0.953 2.3 0.75–7.02 0.145 2.06 0.55–7.69 0.284 2.12 0.58–7.80 0.257
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