From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients
 | 5-year survival | Overall survival | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | |||||||||
HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
NLR | ||||||||||||
  ≤ 4.7 | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
  > 4.7 | 2.58 | 1.45–4.59 | 0.001 | 2.14 | 1.12–4.10 | 0.021 | 2.48 | 1.40–4.40 | 0.002 | 2.11 | 1.11–4.03 | 0.023 |
Gender | ||||||||||||
 Female | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Male | 1.11 | 0.67–1.83 | 0.681 | 1.22 | 0.72–2.04 | 0.459 | 1.18 | 0.72–1.93 | 0.517 | 1.29 | 0.78–2.16 | 0.324 |
Age | ||||||||||||
  ≤ 72 | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
  > 72 | 2.05 | 1.25–3.35 | 0.004 | 2.30 | 1.37–3.87 | 0.002 | 2.13 | 1.32–3.46 | 0.002 | 2.41 | 1.45–4.01 | 0.001 |
Primary tumor | ||||||||||||
 Right colon | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Left colon | 0.88 | 0.42–1.82 | 0.73 | 0.79 | 0.37–1.70 | 0.552 | 0.84 | 0.41–1.72 | 0.627 | 0.76 | 0.35–1.61 | 0.467 |
 Rectum | 1.35 | 0.79–2.32 | 0.275 | 1.38 | 0.76–2.50 | 0.283 | 1.35 | 0.80–2.29 | 0.262 | 1.37 | 0.77–2.44 | 0.289 |
Grade | ||||||||||||
 Low | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Medium + High | 1 | 0.55–1.80 | 0.995 | 0.99 | 0.53–1.85 | 0.98 | 1.04 | 0.58–1.87 | 0.891 | 1 | 0.54–1.86 | 0.989 |
T | ||||||||||||
 T1 | 1 |  |  |  |  |  |  |  |  |  |  |  |
 T2 | 2.08 | 0.26–16.63 | 0.491 |  |  |  |  |  |  |  |  |  |
 T3 | 4.25 | 0.59–30.76 | 0.152 |  |  |  |  |  |  |  |  |  |
 T4 | 8.08 | 1.03–63.13 | 0.046 |  |  |  |  |  |  |  |  |  |
N | ||||||||||||
 N0 | 1 |  |  |  |  |  |  |  |  |  |  |  |
 N1 | 1.2 | 0.67–2.15 | 0.546 |  |  |  |  |  |  |  |  |  |
 N2 | 3.68 | 2.04–6.63 | 0 |  |  |  |  |  |  |  |  |  |
No lymph nodes yield | ||||||||||||
  ≥ 12 | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
  < 12 | 1.6 | 0.84–3.06 | 0.154 | 1.94 | 0.97–3.91 | 0.063 | 1.65 | 0.88–3.07 | 0.116 | 1.95 | 0.99–3.84 | 0.052 |
Stage | ||||||||||||
 Stage I | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Stage II | 2.35 | 0.97–5.70 | 0.058 | 2.70 | 1.10–6.62 | 0.03 | 2.09 | 0.91–4.80 | 0.08 | 2.41 | 1.04–5.59 | 0.041 |
 Stage III | 3.4 | 1.43–8.13 | 0.006 | 3.66 | 1.48–9.05 | 0.005 | 3.02 | 1.34–6.80 | 0.008 | 3.27 | 1.40–7.64 | 0.006 |
Perineural invasion | ||||||||||||
 No | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Yes | 1.71 | 0.78–3.77 | 0.18 | 0.61 | 0.24–1.54 | 0.297 | 1.66 | 0.76–3.65 | 0.204 | 0.59 | 0.24–1.49 | 0.266 |
Vascular invasion | ||||||||||||
 No | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Yes | 2.51 | 1.42–4.43 | 0.001 | 2.36 | 1.17–4.73 | 0.016 | 2.45 | 1.39–4.31 | 0.002 | 2.29 | 1.15–4.57 | 0.019 |
Lymphatic invasion | ||||||||||||
 No | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Yes | 2.15 | 1.19–3.89 | 0.011 | 1.41 | 0.69–2.89 | 0.344 | 2.23 | 1.26–3.96 | 0.006 | 1.54 | 0.77–3.08 | 0.217 |