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Table 5 Univariate and Multivariate analysis among factors which might affect the 5-year survival and the overall survival (OS)

From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients

  5-year survival Overall survival
Univariate Analysis Multivariate Analysis Univariate Analysis Multivariate Analysis
HR 95% CI p value HR 95% CI p value HR 95% CI p value HR 95% CI p value
NLR
  ≤ 4.7 1    1    1    1   
  > 4.7 2.58 1.45–4.59 0.001 2.14 1.12–4.10 0.021 2.48 1.40–4.40 0.002 2.11 1.11–4.03 0.023
Gender
 Female 1    1    1    1   
 Male 1.11 0.67–1.83 0.681 1.22 0.72–2.04 0.459 1.18 0.72–1.93 0.517 1.29 0.78–2.16 0.324
Age
  ≤ 72 1    1    1    1   
  > 72 2.05 1.25–3.35 0.004 2.30 1.37–3.87 0.002 2.13 1.32–3.46 0.002 2.41 1.45–4.01 0.001
Primary tumor
 Right colon 1    1    1    1   
 Left colon 0.88 0.42–1.82 0.73 0.79 0.37–1.70 0.552 0.84 0.41–1.72 0.627 0.76 0.35–1.61 0.467
 Rectum 1.35 0.79–2.32 0.275 1.38 0.76–2.50 0.283 1.35 0.80–2.29 0.262 1.37 0.77–2.44 0.289
Grade
 Low 1    1    1    1   
 Medium + High 1 0.55–1.80 0.995 0.99 0.53–1.85 0.98 1.04 0.58–1.87 0.891 1 0.54–1.86 0.989
T
 T1 1            
 T2 2.08 0.26–16.63 0.491          
 T3 4.25 0.59–30.76 0.152          
 T4 8.08 1.03–63.13 0.046          
N
 N0 1            
 N1 1.2 0.67–2.15 0.546          
 N2 3.68 2.04–6.63 0          
No lymph nodes yield
  ≥ 12 1    1    1    1   
  < 12 1.6 0.84–3.06 0.154 1.94 0.97–3.91 0.063 1.65 0.88–3.07 0.116 1.95 0.99–3.84 0.052
Stage
 Stage I 1    1    1    1   
 Stage II 2.35 0.97–5.70 0.058 2.70 1.10–6.62 0.03 2.09 0.91–4.80 0.08 2.41 1.04–5.59 0.041
 Stage III 3.4 1.43–8.13 0.006 3.66 1.48–9.05 0.005 3.02 1.34–6.80 0.008 3.27 1.40–7.64 0.006
Perineural invasion
 No 1    1    1    1   
 Yes 1.71 0.78–3.77 0.18 0.61 0.24–1.54 0.297 1.66 0.76–3.65 0.204 0.59 0.24–1.49 0.266
Vascular invasion
 No 1    1    1    1   
 Yes 2.51 1.42–4.43 0.001 2.36 1.17–4.73 0.016 2.45 1.39–4.31 0.002 2.29 1.15–4.57 0.019
Lymphatic invasion
 No 1    1    1    1   
 Yes 2.15 1.19–3.89 0.011 1.41 0.69–2.89 0.344 2.23 1.26–3.96 0.006 1.54 0.77–3.08 0.217
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