Table 3 Univariate analysis between the two groups of patients, after setting the NLR cutoff value at 4.7
From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients
Parameter | NLR ≤ 4.7 (n = 260) | NLR > 4.7 (n = 36) | p-value |
|---|---|---|---|
Gender | |||
Female | 96 | 18 | NS |
Male | 164 | 18 | |
Age (years) | |||
Median + IR | 71 (63–77) | 75.5 (70.5–81) | 0.004 |
Age > 72 | |||
Age ≤ 72 | 144 | 13 | 0.033 |
Age > 72 | 116 | 23 | |
Primary tumor | |||
Right colon | 88 | 15 | NS |
Left colon | 54 | 8 | |
Rectum | 118 | 13 | |
Differentiation | |||
Low | 56 | 7 | NS |
Medium + High | 204 | 29 | |
Τ | |||
T1 | 17 | 1 | NS |
T2 | 49 | 8 | |
T3 | 175 | 20 | |
T4 | 19 | 7 | |
Ν | |||
N0 | 165 | 22 | NS |
N1 | 68 | 9 | |
N2 | 27 | 5 | |
No of lymph nodes harvested | |||
Median + IR | 19 (14–27) | 17 (15–28) | NS |
No of lymph nodes harvested | |||
Lymph nodes ≥12 | 230 | 31 | NS |
Lymph nodes < 12 | 30 | 5 | |
Stage | |||
Stage I | 55 | 6 | NS |
Stage II | 110 | 16 | |
Stage III | 95 | 14 | |
Perineural invasion | |||
No | 246 | 27 | < 0.001 |
Yes | 14 | 9 | |
Vascular invasion | |||
No | 226 | 27 | NS |
Yes | 34 | 9 | |
Lymphatic invasion | |||
No | 227 | 30 | NS |
Yes | 33 | 6 | |
Site of recurrence | |||
Distant | 12 | 4 | NS |
Local | 14 | 1 | |
Follow up | |||
Alive with recurrence | 8 | 0 | 0.036 |
Deaths related to the recurrence | 18 | 5 | |
Deaths unrelated to the disease | 35 | 10 | |
Alive | 199 | 21 | |
Probability for overall survival | |||
Alive | 204 | 21 | 0.012 |
Dead | 56 | 15 | |
Probability for recurrence | |||
No recurrence | 234 | 31 | NS |
Recurrence | 26 | 5 | |