Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma

Table 1 Characteristics of 50 NPC patients

Characteristics	Total	No. of patients
Characteristics	Total	Newly diagnosis (M0, N = 29)	Relapse/Distant metastasis after treatment (N = 21)
Gender
Male	34	19	15
Female	16	10	6
Age (years)
Median (Range)	48 (17–66)	47 (17–66)	49(20–66)
< 50	29	17	12
≥ 50	21	12	9
Pathology type
WHO I	1	1	0
WHO II/III	49	28	21
Stage^a
T-classification
T1	7	5	2
T2	8	5	3
T3	13	7	6
T4	22	12	10
N-classification
N0	4	3	1
N1	8	1	7
N2	29	20	9
N3	9	5	4
TNM stage
I	0	0	0
II	4	2	2
III	19	12	7
IV	27	15	12
Treatment^b
IndCT+RT/CCRT	29	29	0
CT ± RT	15	0	15
Others	6	0	6
pEBV DNA level
Negative	7	2	5
Positive	43	27	16

^a Stage for patients with relapse/distant metastasis after treatment refered to TNM stage at NPC initial diagnosis
^b IndCT = induction chemotherapy, CT = Chemotherapy, RT = radiotherapy, CCRT = concurrent chemoradiotherapy

ISSN: 1471-2407