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Table 1 Characteristics and parameters of the 539 HCC patients

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Characteristics no. (%) 5-year OS (Months) Mean ± SD p-Value 5-year DFS (Months) Mean ± SD p-Value
Gender(n)
 Male 480(89.05) 30.82 ± 20.74 0.524 30.65 ± 20.71 0.566
 Female 59(10.95) 29.71 ± 20.21   19.71 ± 20.21  
Age (years)
  ≥ 53 275(51.02) 32.05 ± 20.57 0.167 31.75 ± 20.55 0.226
  < 53 264(48.98) 29.30 ± 20.71   29.30 ± 20.71  
Stage(n)
 I and II 306(56.77) 38.16 ± 17.84 < 0.001 37.92 ± 17.87 < 0.001
 III and IV 233(43.23) 20.90 ± 20.06   20.87 ± 20.07  
Tumor size(cm)
  ≥ 5 220(40.82) 20.17 ± 19.68 < 0.001 20.14 ± 19.69 < 0.001
  < 5 319(59.18) 37.96 ± 18.06   37.73 ± 18.09  
Tumor number
 Single 335(62.15) 33.71 ± 20.02 0.001 33.55 ± 20.04 0.001
 Multiple 192(35.62) 26.74 ± 20.75   26.60 ± 20.66  
Node stage
 N0 502(93.14) 31.35 ± 20.34 0.016 31.19 ± 20.32 0.017
 N1–2 37(6.86) 21.92 ± 23.30   21.92 ± 23.30  
Distant metastases
 Yes 31(5.75) 24.52 ± 23.08 0.102 24.52 ± 23.08 0.108
 No 508(94.25) 31.08 ± 20.48   30.92 ± 20.45  
BMI (kg/m2)
  ≥ 24.0 174(32.28) 32.70 ± 20.70 0.234 32.44 ± 20.58 0.292
 18.5–23.9 319(59.18) 29.94 ± 20.74   29.83 ± 20.77  
  < 18.5 45(8.35) 28.80 ± 19.90   28.80 ± 19.90  
Alcohol behavior
 Previous/Current 200(37.11) 30.02 ± 21.18 0.683 29.66 ± 21.08 0.535
 Never 339(62.89) 31.10 ± 20.38   21.08 ± 20.40  
Family history of cancer
 Yes 138(25.60) 32.21 ± 20.52 0.362 32.21 ± 20.52 0.303
 No 401(74.40) 30.18 ± 20.72   29.98 ± 20.68  
HBs Ag
 Negative 61 (11.32) 30.23 ± 19.87 < 0.001 30.22 ± 19.87 < 0.001
 Positive 362(67.16) 39.98 ± 18.05   39.77 ± 18.05  
HBe Ag
 Negative 361(66.98) 31.75 ± 20.65 0.283 31.56 ± 20.64 0.317
 Positive 62(11.50) 28.44 ± 21.28   28.44 ± 21.28  
AFP (ng/mL)
  ≥ 400 195(36.18) 24.35 ± 20.46 < 0.001 24.19 ± 20.40 < 0.001
  < 400 323(59.93) 35.85 ± 19.18   35.70 ± 19.19  
ALB
  ≥ 41.35 271(50.28%) 35.40 ± 19.56 < 0.001 35.20 ± 19.58 < 0.001
  < 41.35 268(49.72%) 25.95 ± 20.71   25.85 ± 20.66  
TBIL
  ≥ 15.95 209(38.78%) 26.08 ± 21.20 < 0.001 26.02 ± 21.24 < 0.001
  < 15.95 330(61.22%) 33.63 ± 19.80   33.42 ± 19.78  
HDL(mmol/L)
  ≥ 1.16 253(46.94) 34.25 ± 19.56 < 0.001 34.00 ± 19.61 < 0.001
  < 1.16 286(53.06) 27.56 ± 21.14   27.50 ± 21.08  
LDL(mmol/L)
  ≥ 3.1 276(51.21) 30.72 ± 20.87 0.924 30.64 ± 20.82 0.870
  < 3.1 263(48.79) 30.68 ± 20.49   30.46 ± 20.49  
ApoA-1(g/L)
  ≥ 1.09 279(51.76) 36.22 ± 19.36 < 0.001 35.99 ± 19.42 < 0.001
  < 1.09 260(48.24) 24.78 ± 20.42   24.71 ± 20.35  
ApoB(g/L)
  ≥ 1.1 97(18.00) 29.91 ± 21.97 0.717 29.87 ± 21.96 0.761
  < 1.1 442(82.00) 30.88 ± 20.39   30.70 ± 20.37  
CRP(mg/L)
  ≥ 3.0 290(53.80) 22.63 ± 20.25 < 0.001 22.57 ± 20.29 < 0.001
  < 3.0 249(46.20) 40.10 ± 16.85   39.85 ± 16.84  
  1. Abbreviations:OS overall survival, DFS disease-free survival, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B, CRP C-reactive protein