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Table 1 Characteristics and parameters of the 539 HCC patients

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Characteristics

no. (%)

5-year OS (Months) Mean ± SD

p-Value

5-year DFS (Months) Mean ± SD

p-Value

Gender(n)

 Male

480(89.05)

30.82 ± 20.74

0.524

30.65 ± 20.71

0.566

 Female

59(10.95)

29.71 ± 20.21

 

19.71 ± 20.21

 

Age (years)

  ≥ 53

275(51.02)

32.05 ± 20.57

0.167

31.75 ± 20.55

0.226

  < 53

264(48.98)

29.30 ± 20.71

 

29.30 ± 20.71

 

Stage(n)

 I and II

306(56.77)

38.16 ± 17.84

< 0.001

37.92 ± 17.87

< 0.001

 III and IV

233(43.23)

20.90 ± 20.06

 

20.87 ± 20.07

 

Tumor size(cm)

  ≥ 5

220(40.82)

20.17 ± 19.68

< 0.001

20.14 ± 19.69

< 0.001

  < 5

319(59.18)

37.96 ± 18.06

 

37.73 ± 18.09

 

Tumor number

 Single

335(62.15)

33.71 ± 20.02

0.001

33.55 ± 20.04

0.001

 Multiple

192(35.62)

26.74 ± 20.75

 

26.60 ± 20.66

 

Node stage

 N0

502(93.14)

31.35 ± 20.34

0.016

31.19 ± 20.32

0.017

 N1–2

37(6.86)

21.92 ± 23.30

 

21.92 ± 23.30

 

Distant metastases

 Yes

31(5.75)

24.52 ± 23.08

0.102

24.52 ± 23.08

0.108

 No

508(94.25)

31.08 ± 20.48

 

30.92 ± 20.45

 

BMI (kg/m2)

  ≥ 24.0

174(32.28)

32.70 ± 20.70

0.234

32.44 ± 20.58

0.292

 18.5–23.9

319(59.18)

29.94 ± 20.74

 

29.83 ± 20.77

 

  < 18.5

45(8.35)

28.80 ± 19.90

 

28.80 ± 19.90

 

Alcohol behavior

 Previous/Current

200(37.11)

30.02 ± 21.18

0.683

29.66 ± 21.08

0.535

 Never

339(62.89)

31.10 ± 20.38

 

21.08 ± 20.40

 

Family history of cancer

 Yes

138(25.60)

32.21 ± 20.52

0.362

32.21 ± 20.52

0.303

 No

401(74.40)

30.18 ± 20.72

 

29.98 ± 20.68

 

HBs Ag

 Negative

61 (11.32)

30.23 ± 19.87

< 0.001

30.22 ± 19.87

< 0.001

 Positive

362(67.16)

39.98 ± 18.05

 

39.77 ± 18.05

 

HBe Ag

 Negative

361(66.98)

31.75 ± 20.65

0.283

31.56 ± 20.64

0.317

 Positive

62(11.50)

28.44 ± 21.28

 

28.44 ± 21.28

 

AFP (ng/mL)

  ≥ 400

195(36.18)

24.35 ± 20.46

< 0.001

24.19 ± 20.40

< 0.001

  < 400

323(59.93)

35.85 ± 19.18

 

35.70 ± 19.19

 

ALB

  ≥ 41.35

271(50.28%)

35.40 ± 19.56

< 0.001

35.20 ± 19.58

< 0.001

  < 41.35

268(49.72%)

25.95 ± 20.71

 

25.85 ± 20.66

 

TBIL

  ≥ 15.95

209(38.78%)

26.08 ± 21.20

< 0.001

26.02 ± 21.24

< 0.001

  < 15.95

330(61.22%)

33.63 ± 19.80

 

33.42 ± 19.78

 

HDL(mmol/L)

  ≥ 1.16

253(46.94)

34.25 ± 19.56

< 0.001

34.00 ± 19.61

< 0.001

  < 1.16

286(53.06)

27.56 ± 21.14

 

27.50 ± 21.08

 

LDL(mmol/L)

  ≥ 3.1

276(51.21)

30.72 ± 20.87

0.924

30.64 ± 20.82

0.870

  < 3.1

263(48.79)

30.68 ± 20.49

 

30.46 ± 20.49

 

ApoA-1(g/L)

  ≥ 1.09

279(51.76)

36.22 ± 19.36

< 0.001

35.99 ± 19.42

< 0.001

  < 1.09

260(48.24)

24.78 ± 20.42

 

24.71 ± 20.35

 

ApoB(g/L)

  ≥ 1.1

97(18.00)

29.91 ± 21.97

0.717

29.87 ± 21.96

0.761

  < 1.1

442(82.00)

30.88 ± 20.39

 

30.70 ± 20.37

 

CRP(mg/L)

  ≥ 3.0

290(53.80)

22.63 ± 20.25

< 0.001

22.57 ± 20.29

< 0.001

  < 3.0

249(46.20)

40.10 ± 16.85

 

39.85 ± 16.84

 
  1. Abbreviations:OS overall survival, DFS disease-free survival, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B, CRP C-reactive protein