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Table 4 Univariate and multivariate analysis of the correlations between prognostic value and disease-free and overall survival rates in 185 patients with type I endometrial cancer

From: BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway

Characteristics

Disease-free survival

Overall survival

HR

95% CI

p

HR

95% CI

p

Univariate analysis

 Age

2.603

1.321–5.166

0.006

2.777

1.348–5.718

0.006

 FIGO stage

2.956

1.454–6.011

0.003

3.420

1.600–7.312

0.002

 Differentiation

5.221

2.628–10.375

2.39E−6

5.516

2.676–11.372

3.72E−6

 Myometrial invasion

4.911

2.477–9.738

5.17E−6

5.411

2.635–11.112

4.25E−6

 LVSI

6.352

2.940–13.722

2.55E−6

6.675

3.046–14.627

2.11E−6

 LNM

14.51

6.994–30.103

6.79E−13

15.02

6.964–32.384

4.84E−12

 Cervical stromal involvement

1.589

0.797–3.170

0.188

1.932

0.942–3.959

0.072

 BKCa expression

1.121

0.558–2.253

0.749

1.123

0.541–2.331

0.756

 ERK1/2 expression

0.594

0.300–1.175

0.134

0.546

0.267–1.120

0.099

 p-ERK1/2 expression

4.149

1.800–9.563

0.001

4.358

1.781–10.664

0.001

Multivariate analysis

 Age

1.717

0.842–3.503

0.137

1.912

0.909–4.025

0.088

 FIGO stage

1.268

0.538–2.986

0.587

1.607

0.648–3.983

0.306

 Differentiation

3.111

1.413–6.851

0.005

3.494

1.520–8.034

0.003

 Myometrial invasion

3.096

1.430–6.703

0.004

3.648

1.642–8.106

0.001

 LVSI

0.503

0.154–1.647

0.256

0.635

0.196–2.050

0.447

 LNM

5.008

1.513–16.573

0.008

3.832

1.145–12.826

0.029

 p-ERK1/2 expression

3.912

1.542–9.927

0.004

3.796

1.415–10.180

0.008

  1. FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis, HR hazard ratio, 95% CI, 95% confidence interval