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Table 4 Univariate and multivariate analysis of the correlations between prognostic value and disease-free and overall survival rates in 185 patients with type I endometrial cancer

From: BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway

Characteristics Disease-free survival Overall survival
HR 95% CI p HR 95% CI p
Univariate analysis
 Age 2.603 1.321–5.166 0.006 2.777 1.348–5.718 0.006
 FIGO stage 2.956 1.454–6.011 0.003 3.420 1.600–7.312 0.002
 Differentiation 5.221 2.628–10.375 2.39E−6 5.516 2.676–11.372 3.72E−6
 Myometrial invasion 4.911 2.477–9.738 5.17E−6 5.411 2.635–11.112 4.25E−6
 LVSI 6.352 2.940–13.722 2.55E−6 6.675 3.046–14.627 2.11E−6
 LNM 14.51 6.994–30.103 6.79E−13 15.02 6.964–32.384 4.84E−12
 Cervical stromal involvement 1.589 0.797–3.170 0.188 1.932 0.942–3.959 0.072
 BKCa expression 1.121 0.558–2.253 0.749 1.123 0.541–2.331 0.756
 ERK1/2 expression 0.594 0.300–1.175 0.134 0.546 0.267–1.120 0.099
 p-ERK1/2 expression 4.149 1.800–9.563 0.001 4.358 1.781–10.664 0.001
Multivariate analysis
 Age 1.717 0.842–3.503 0.137 1.912 0.909–4.025 0.088
 FIGO stage 1.268 0.538–2.986 0.587 1.607 0.648–3.983 0.306
 Differentiation 3.111 1.413–6.851 0.005 3.494 1.520–8.034 0.003
 Myometrial invasion 3.096 1.430–6.703 0.004 3.648 1.642–8.106 0.001
 LVSI 0.503 0.154–1.647 0.256 0.635 0.196–2.050 0.447
 LNM 5.008 1.513–16.573 0.008 3.832 1.145–12.826 0.029
 p-ERK1/2 expression 3.912 1.542–9.927 0.004 3.796 1.415–10.180 0.008
  1. FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis, HR hazard ratio, 95% CI, 95% confidence interval