Skip to main content

Table 3 The correlations between the expressions of BKCa, ERK1/2 and p-ERK1/2 proteins and the clinicopathological parameters in 185 cases with type I endometrial cancer

From: BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway

Characteristics BKCa, n (%) p-value ERK1/2, n (%) p-value p-ERK1/2, n (%) p-value
Low High Low High Low High
Age    0.119    0.151    0.179
 ≤ 60 82(44.3) 40(21.6)   54(29.2) 68(36.8)   65(35.1) 57(30.8)  
 >  60 35(18.9) 28(15.1)   21(11.4) 42(22.7)   27(14.6) 36(19.5)  
FIGO stage    0.004    0.271    0.012
 <II 80(43.2) 32(17.3)   49(26.5) 63(34.1)   64(34.6) 48(25.9)  
 ≥II 37(20.0) 36(19.5)   26(14.1) 47(25.4)   28(15.1) 45(24.3)  
Differentiation    0.733    0.345    0.623
 Well/moderate 92(49.7) 52(28.1)   61(33.0) 83(44.9)   73(39.5) 71(38.4)  
 Poor 25(13.5) 16(8.6)   14(7.6) 27(14.6)   19(10.3) 22(11.9)  
Myometrial invasion    0.958    0.066    0.201
 < 1/2 95(51.4) 55(29.7)   56(30.3) 94(50.8)   78(42.2) 72(38.9)  
 ≥1/2 22(11.9) 13(7.0)   19(10.3) 16(8.6)   14(7.6) 21(11.4)  
Cervical stromal involvement    0.107    0.457    0.014
 No 84(45.4) 41(22.2)   53(28.6) 72(38.9)   70(37.8) 55(29.7)  
 Yes 33(17.8) 27(14.6)   22(11.9) 38(20.5)   22(11.9) 38(20.5)  
LVSI    0.104    0.183    0.046
 No 112(60.5) 60(32.4)   72(38.9) 100(54.1)   89(48.1) 83(44.9)  
 Yes 5(2.7) 8(4.3)   3(1.6) 10(5.4)   3(1.6) 10(5.4)  
LNM    0.011    0.407    0.018
 No 114(61.6) 59(31.9)   72(38.9) 101(54.6)   90(48.6) 83(44.9)  
 Yes 3(1.6) 9(4.9)   3(1.6) 9(4.9)   2(1.1) 10(5.4)  
  1. FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis