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Table 3 The correlations between the expressions of BKCa, ERK1/2 and p-ERK1/2 proteins and the clinicopathological parameters in 185 cases with type I endometrial cancer

From: BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway

Characteristics

BKCa, n (%)

p-value

ERK1/2, n (%)

p-value

p-ERK1/2, n (%)

p-value

Low

High

Low

High

Low

High

Age

  

0.119

  

0.151

  

0.179

 ≤ 60

82(44.3)

40(21.6)

 

54(29.2)

68(36.8)

 

65(35.1)

57(30.8)

 

 >  60

35(18.9)

28(15.1)

 

21(11.4)

42(22.7)

 

27(14.6)

36(19.5)

 

FIGO stage

  

0.004

  

0.271

  

0.012

 <II

80(43.2)

32(17.3)

 

49(26.5)

63(34.1)

 

64(34.6)

48(25.9)

 

 ≥II

37(20.0)

36(19.5)

 

26(14.1)

47(25.4)

 

28(15.1)

45(24.3)

 

Differentiation

  

0.733

  

0.345

  

0.623

 Well/moderate

92(49.7)

52(28.1)

 

61(33.0)

83(44.9)

 

73(39.5)

71(38.4)

 

 Poor

25(13.5)

16(8.6)

 

14(7.6)

27(14.6)

 

19(10.3)

22(11.9)

 

Myometrial invasion

  

0.958

  

0.066

  

0.201

 < 1/2

95(51.4)

55(29.7)

 

56(30.3)

94(50.8)

 

78(42.2)

72(38.9)

 

 ≥1/2

22(11.9)

13(7.0)

 

19(10.3)

16(8.6)

 

14(7.6)

21(11.4)

 

Cervical stromal involvement

  

0.107

  

0.457

  

0.014

 No

84(45.4)

41(22.2)

 

53(28.6)

72(38.9)

 

70(37.8)

55(29.7)

 

 Yes

33(17.8)

27(14.6)

 

22(11.9)

38(20.5)

 

22(11.9)

38(20.5)

 

LVSI

  

0.104

  

0.183

  

0.046

 No

112(60.5)

60(32.4)

 

72(38.9)

100(54.1)

 

89(48.1)

83(44.9)

 

 Yes

5(2.7)

8(4.3)

 

3(1.6)

10(5.4)

 

3(1.6)

10(5.4)

 

LNM

  

0.011

  

0.407

  

0.018

 No

114(61.6)

59(31.9)

 

72(38.9)

101(54.6)

 

90(48.6)

83(44.9)

 

 Yes

3(1.6)

9(4.9)

 

3(1.6)

9(4.9)

 

2(1.1)

10(5.4)

 
  1. FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis