Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patients

Zheng, Bo-Hao; Liu, Long-Zi; Zhang, Zhi-Zhi; Shi, Jie-Yi; Dong, Liang-Qing; Tian, Ling-Yu; Ding, Zhen-bin; Ji, Yuan; Rao, Sheng-Xiang; Zhou, Jian; Fan, Jia; Wang, Xiao-Ying; Gao, Qiang

doi:10.1186/s12885-018-5024-z

BMC Cancer

Table 3 Uni-and Multivariate analyses of predictors of postoperative survival in training and validation cohorts

From: Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patients

Variables		Training cohort						Validation cohort
		Univariate analysis			Multivariate analysis			Multivariate analysis
		HR	95%CI	p	HR	95%CI	p	HR	95%CI	p
Gender	Male	0.931	0.451–1.923	0.847	\	\	\
Gender	Female	0.931	0.451–1.923	0.847	\	\	\
Tumor size(cm)	≤3	2.822	1.406–5.650	0.004	1.910	0.897–4.070	0.035	\	\	0.139
Tumor size(cm)	> 3	2.822	1.406–5.650	0.004	1.910	0.897–4.070	0.035	\	\	0.139
Vascular invasion	Present	3.52	1.701–7.287	0.001	1.794	0.797–4.037	0.008	\	\	0.982
Vascular invasion	Absent	3.52	1.701–7.287	0.001	1.794	0.797–4.037	0.008	\	\	0.982
Micro-vascular invasion	Present	1.084	0.574–2.051	0.803	\	\	\	\	\	\
Micro-vascular invasion	Absent	1.084	0.574–2.051	0.803	\	\	\	\	\	\
Differentiation	III-IV	1.515	0.886–2.592	0.129	\	\	\	\	\	\
Differentiation	I-II	1.515	0.886–2.592	0.129	\	\	\	\	\	\
Liver Cirrhosis	Yes	1.113	0.838–1.479	0.458	\	\	\	\	\	\
Liver Cirrhosis	No	1.113	0.838–1.479	0.458	\	\	\	\	\	\
HBsAg	Present	1.557	0.662–3.664	0.31	\	\	\	\	\	\
HBsAg	Absent	1.557	0.662–3.664	0.31	\	\	\	\	\	\
Tumor encapsulation	Absent	2.105	1.155–3.846	0.015	2.326	1.272–4.255	0.006	\	\	0.394
Tumor encapsulation	Present	2.105	1.155–3.846	0.015	2.326	1.272–4.255	0.006	\	\	0.394
Rad-score	≤4.32	2.387	1.321–4.310	0.004	2.283	1.261–4.132	0.006	3.236	1.416–7.407	0.005
Rad-score	> 4.32	2.387	1.321–4.310	0.004	2.283	1.261–4.132	0.006	3.236	1.416–7.407	0.005
DBIL, μmol/L		1.015	0.998–1.031	0.084	\	\	\	\	\
TBIL, μmol/L		1.012	0.998–1.026	0.102	\	\	\	\	\	\
ALT, U/L		0.998	0.991–1.005	0.57	\	\	\	\	\	\
AST, U/L		1.000	0.995–1.005	0.946	\	\	\	\	\	\
AFP, ng/ml		1.000	1.000–1.000	0.189	\	\	\	\	\	\
ALB, g/L		1.020	0.964–1.079	0.495	\	\	\	\	\	\
GGT, U/L		1.004	1.003–1.006	< 0.0001	1.004	1.002–1.006	< 0.0001	\	\	0.249

Abbreviations: ALB Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, DBIL Direct Bilirubin, TBIL Total bilirubin, GGT, γ-Glutamyltransferase, AFP alpha-fetoprotein

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