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Table 3 Multivariate analysis of prognostic factors in 965 patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation

From: Elevated platelet count is a negative predictive and prognostic marker in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: a retrospective multi-institutional study on 965 patients

 

Overall Survival

Disease-Free Survival

Reference

HR

(CI 95%)

p

HR

(CI 95%)

p

Age

 

1.04

1.03–1.06

0.000

1.03

(1.01–1.04)

0.000

Sex

Female

0.79

0.59–1.06

0.113

0.82

(0.63–1.06)

0.127

cT

I-II

1.58

0.88–2.84

0.127

1.18

(0.74–1.88)

0.495

cN

0

0.93

0.71–1.23

0.634

1.07

(0.84–1.37)

0.57

Platelets count

< 300 × 109/L

1.45

1.10–1.92

0.009

1.39

(1.09–1.79)

0.009

Distance from anal verge

< 5 cms

0.62

0.47–0.81

0.001

0.59

(0.46–0.75)

0.000

Interval between CRT and Surgery

< 8 weeks

1.04

0.78–1.38

0.798

1.18

(0.91–1.54)

0.213

  1. HR hazard ratio, cT Clinical primary tumor stage, cN Clinical lymph node stage, CRT chemoradiation