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Fig. 4 | BMC Cancer

Fig. 4

From: Epithelial cell adhesion molecule (EpCAM) is involved in prostate cancer chemotherapy/radiotherapy response in vivo

Fig. 4

In vivo effects of EpCAM-KD on radiosensitivity in s.c. and orthotopic animal models. a Tumour growth curves representing the s.c. mouse model are shown for RT or SC groups of PC-3-EpCAM-KD and PC-3-EpCAM-scr cell lines. Significant differences were seen between PC-3-EpCAM-KD-RT and PC-3-EpCAM-KD-SC groups (P < 0.01), PC-3-EpCAM-scr-RT and PC-3-EpCAM-scr-SC groups (P < 0.01), PC-3-EpCAM-KD-SC and PC-3-EpCAM-scr-SC groups (P < 0.05), respectively (n = 4). b The ratios of RT versus SC tumour volumes (RT/SC) were calculated and plotted from the start of RT to the end of experiments in s.c. mouse model. The ratio of PC-3-EpCAM-KD tumour volumes decreased faster in response to RT compared to the sham irradiation (P < 0.05, n = 4). c Typical images of PC-3-EpCAM-KD and PC-3-EpCAM-scr s.c. xenografts (at the end of the experiment, 5 weeks post-RT treatment). d Tumour growth curves representing the orthotopic mouse model are shown for RT or SC groups of PC-3-EpCAM-KD and PC-3-EpCAM-scr cell lines. Significant differences were seen between PC-3-EpCAM-KD-RT and PC-3-EpCAM-KD-SC groups (P < 0.01), PC-3-EpCAM-scr-RT and PC-3-EpCAM-scr-SC groups (P < 0.05), PC-3-EpCAM-KD-SC and PC-3-EpCAM-scr-SC groups (P < 0.05), respectively (n = 4). e The ratios of RT versus SC tumour volumes (RT/SC) were calculated and plotted from the start of RT to the end of experiments in orthotopic mouse model. The ratio of PC-3-EpCAM-KD tumour volumes decreased faster in response to RT compared to the sham irradiation (P < 0.05, n = 4). f Representative images of PC-3-EpCAM-KD and PC-3-EpCAM-scr orthotopic xenografts (at the end of the experiment, 5 weeks post RT treatment). KD, knock-down; SC, sham control; RT, radiotherapy; scr, scrambled shRNA control

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