Fig. 2

Tumour growth of PC-3-EpCAM-KD and PC-3-EpCAM-scr cells in CaP s.c. and orthotopic animal models. a The graph is shown for tumour growth curves of PC-3-EpCAM-KD and PC-3-EpCAM-scr in s.c. xenograft model. The weekly measurements of PC-3-EpCAM-KD xenografts show a significant reduced tumour growth rate compared to the PC-3-EpCAM-scr group (n = 10, mean ± SD, P < 0.05). b At the end of the experiment, tumour weight from PC-3-EpCAM-KD group mice was significantly decreased compared to that from PC-3-EpCAM-scr group mice in s.c. model (n = 10, mean ± SD, * indicates P < 0.05). c At the end of the experiment, representative images of tumours from s.c. xenografts are shown. d The graph represents for PC-3-EpCAM-KD and PC-3-EpCAM-scr tumour growth curves in the orthotopic xenograft model (n = 10, mean ± SD, P < 0.05). e Tumour weight from PC-3-EpCAM-KD group mice was shown as significantly decreased compared to that from PC-3-EpCAM-scr group mice in orthotopic model (n = 10, mean ± SD, * indicates P < 0.05). f Representative images of tumours from orthotopic xenografts are shown for PC-3-EpCAM-KD and PC-3-EpCAM-scr tumour xenografts. KD, knock-down; scr, scrambled shRNA control