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Table 3 Multivariate Cox model analyses for overall and disease-specific survival

From: Does fibrosis have an impact on survival of patients with hepatocellular carcinoma: evidence from the SEER database?

Variables Overall Survival Disease-specific Survival
HR (95%CI) P Value HR (95%CI) P Value
Age <  60 Reference   Reference  
≥ 60 1.12(1.07–1.18) < 0.001 1.13(1.07–1.19) < 0.001
Sex Male Reference   Reference  
Female 0.94(0.89–0.99) 0.042 0.96(0.90–1.02) 0.184
Ethnicity White Reference   Reference  
Asian or Pacific Island 0.77(0.72–0.82) < 0.001 0.76(0.71–0.82) < 0.001
Black 1.04(0.97–1.12) 0.228 1.01(0.94–1.09) 0.807
American Indian/Alaska Native 1.07(0.90–1.27) 0.464 1.11(0.92–1.34) 0.279
Unknown 0.63(0.42–0.94) 0.022 0.67(0.43–1.04) 0.073
Marital Status Married Reference   Reference  
Unmarried 1.13(1.08–1.19) < 0.001 1.10(1.05–1.16) < 0.001
Unknown 1.06(0.94–1.20) 0.346 1.00(0.87–1.14) 0.941
Year of Diagnosis 2004–2007 Reference   Reference  
2008–2011 0.80(0.76–0.85) < 0.001 0.82(0.77–0.87) < 0.001
2012–2014 0.75(0.70–0.80) < 0.001 0.76(0.70–0.82) < 0.001
TNM Stage I Reference   Reference  
II 1.14(1.07–1.22) < 0.001 1.25(1.16–1.35) < 0.001
III 2.29(2.15–2.45) < 0.001 2.70(2.51–2.90) < 0.001
IV 3.48(3.21–3.77) < 0.001 4.13(3.79–4.51) < 0.001
Unknown 1.99(1.81–2.18) < 0.001 2.17(1.96–2.41) < 0.001
AFP Negative Reference   Reference  
Positive 1.41(1.32–1.50) < 0.001 1.46(1.36–1.57) < 0.001
Borderline 0.82(0.52–1.29) 0.385 1.01(0.63–1.61) 0.978
Unknown 1.34(1.23–1.45) < 0.001 1.34(1.22–1.48) < 0.001
Tumor Size <  2 cm Reference   Reference  
≥ 2 cm 1.61(1.48–1.77) < 0.001 1.85(1.66–2.06) < 0.001
Unknown 2.69(2.40–3.02) < 0.001 3.15(2.76–3.59) < 0.001
Therapy None Reference   Reference  
Tumor Destruction 0.53(0.49–0.57) < 0.001 0.50(0.46–0.55) < 0.001
Surgical Resection 0.38(0.35–0.42) < 0.001 0.37(0.33–0.41) < 0.001
Liver Transplantation 0.16(0.15–0.19) < 0.001 0.10(0.08–0.12) < 0.001
Unknown 0.76(0.51–1.13) 0.174 0.74(0.48–1.14) 0.175
Fibrosis Score 0–4 Reference   Reference  
5–6 1.09(1.02–1.16) 0.007 1.05(0.98–1.13) 0.139