Table 3 Multivariate Cox model analyses for overall and disease-specific survival

Age

<  60

Reference

Reference

≥ 60

1.12(1.07–1.18)

1.13(1.07–1.19)

Sex

Male

Reference

Reference

Female

0.94(0.89–0.99)

0.96(0.90–1.02)

Ethnicity

White

Reference

Reference

Asian or Pacific Island

0.77(0.72–0.82)

0.76(0.71–0.82)

Black

1.04(0.97–1.12)

1.01(0.94–1.09)

American Indian/Alaska Native

1.07(0.90–1.27)

1.11(0.92–1.34)

Unknown

0.63(0.42–0.94)

0.67(0.43–1.04)

Marital Status

Married

Reference

Reference

Unmarried

1.13(1.08–1.19)

1.10(1.05–1.16)

Unknown

1.06(0.94–1.20)

1.00(0.87–1.14)

Year of Diagnosis

2004–2007

Reference

Reference

2008–2011

0.80(0.76–0.85)

0.82(0.77–0.87)

2012–2014

0.75(0.70–0.80)

0.76(0.70–0.82)

TNM Stage

I

Reference

Reference

II

1.14(1.07–1.22)

1.25(1.16–1.35)

III

2.29(2.15–2.45)

2.70(2.51–2.90)

IV

3.48(3.21–3.77)

4.13(3.79–4.51)

Unknown

1.99(1.81–2.18)

2.17(1.96–2.41)

AFP

Negative

Reference

Reference

Positive

1.41(1.32–1.50)

1.46(1.36–1.57)

Borderline

0.82(0.52–1.29)

1.01(0.63–1.61)

Unknown

1.34(1.23–1.45)

1.34(1.22–1.48)

Tumor Size

<  2 cm

Reference

Reference

≥ 2 cm

1.61(1.48–1.77)

1.85(1.66–2.06)

Unknown

2.69(2.40–3.02)

3.15(2.76–3.59)

Therapy

None

Reference

Reference

Tumor Destruction

0.53(0.49–0.57)

0.50(0.46–0.55)

Surgical Resection

0.38(0.35–0.42)

0.37(0.33–0.41)

Liver Transplantation

0.16(0.15–0.19)

0.10(0.08–0.12)

Unknown

0.76(0.51–1.13)

0.74(0.48–1.14)

Fibrosis Score

0–4

Reference

Reference

5–6

1.09(1.02–1.16)

1.05(0.98–1.13)