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Table 2 Univariate Cox model analyses for overall and disease-specific survival

From: Does fibrosis have an impact on survival of patients with hepatocellular carcinoma: evidence from the SEER database?

Variables Overall Survival Disease-specific Survival
HR (95%CI) P Value HR (95%CI) P Value
Age <  60 Reference   Reference  
≥ 60 1.12(1.07–1.17) < 0.001 1.13(1.07–1.19) < 0.001
Sex Male Reference   Reference  
Female 0.89(0.84–0.95) < 0.001 0.89(0.84–0.95) < 0.001
Ethnicity White Reference   Reference  
Asian or Pacific Island 0.73(0.68–0.78) < 0.001 0.73(0.68–0.78) < 0.001
Black 1.16(1.08–1.24) < 0.001 1.14(1.05–1.23) 0.001
American Indian/Alaska Native 1.23(1.03–1.46) 0.020 1.28(1.06–1.54) 0.012
Unknown 0.59(0.39–0.88) 0.009 0.60(0.39–0.94) 0.024
Marital Status Married Reference   Reference  
Unmarried 1.34(1.28–1.40) < 0.001 1.31(1.25–1.38) < 0.001
Unknown 1.23(1.09–1.39) < 0.001 1.17(1.02–1.34) 0.028
Year of Diagnosis 2004–2007 Reference   Reference  
2008–2011 0.92(0.87–0.97) 0.002 0.94(0.88–1.00) 0.039
2012–2014 0.85(0.79–0.90) < 0.001 0.85(0.79–0.91) < 0.001
TNM Stage I Reference   Reference  
II 1.17(1.10–1.25) < 0.001 1.28(1.19–1.38) < 0.001
III 3.24(3.04–3.45) < 0.001 3.96(3.70–4.25) < 0.001
IV 6.11(5.67–6.60) < 0.001 7.56(6.96–8.22) < 0.001
Unknown 3.86(3.54–4.20) < 0.001 4.39(3.99–4.83) < 0.001
SEER Stage Localized Reference   Reference  
Regional 2.25(2.14–2.37) < 0.001 2.56(2.42–2.71) < 0.001
Distant 5.30(4.95–5.69) < 0.001 6.29(5.83–6.78) < 0.001
Unstaged 3.96(3.41–4.61) < 0.001 4.06(3.42–4.81) < 0.001
Pathological Grade Well differentiated Reference   Reference  
Moderately differentiated 1.04(0.95–1.14) 0.399 1.09(0.99–1.21) 0.088
Poorly differentiated 1.74(1.56–1.94) < 0.001 2.00(1.78–2.26) < 0.001
Undifferentiated 1.65(1.22–2.23) 0.001 1.81(1.30–2.51) < 0.001
Unknown 1.83(1.70–1.98) < 0.001 1.91(1.75–2.08) < 0.001
AFP Negative Reference   Reference  
Positive 1.77(1.66–1.88) < 0.001 1.88(1.76–2.02) < 0.001
Borderline 1.16(0.74–1.83) 0.513 1.45(0.91–2.31) 0.119
Unknown 1.60(1.48–1.74) < 0.001 1.64(1.49–1.80) < 0.001
Tumor Size <  2 cm Reference   Reference  
≥ 2 cm 2.20(2.01–2.40) < 0.001 2.69(2.41–2.99) < 0.001
Unknown 6.98(6.28–7.75) < 0.001 8.94(7.90–10.12) < 0.001
Therapy None Reference   Reference  
Tumor Destruction 0.40(0.37–0.43) < 0.001 0.36(0.33–0.40) < 0.001
Surgical Resection 0.29(0.27–0.32) < 0.001 0.28(0.26–0.31) < 0.001
Liver Transplantation 0.12(0.10–0.13) < 0.001 0.07(0.06–0.08) < 0.001
Unknown 1.34(0.91–1.99) 0.140 1.35(0.88–2.07) 0.174
Fibrosis Score 0–4 Reference   Reference  
5–6 1.16(1.10–1.23) < 0.001 1.11(1.05–1.19) < 0.001