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Table 2 Univariate Cox model analyses for overall and disease-specific survival

From: Does fibrosis have an impact on survival of patients with hepatocellular carcinoma: evidence from the SEER database?

Variables

Overall Survival

Disease-specific Survival

HR (95%CI)

P Value

HR (95%CI)

P Value

Age

<  60

Reference

 

Reference

 

≥ 60

1.12(1.07–1.17)

< 0.001

1.13(1.07–1.19)

< 0.001

Sex

Male

Reference

 

Reference

 

Female

0.89(0.84–0.95)

< 0.001

0.89(0.84–0.95)

< 0.001

Ethnicity

White

Reference

 

Reference

 

Asian or Pacific Island

0.73(0.68–0.78)

< 0.001

0.73(0.68–0.78)

< 0.001

Black

1.16(1.08–1.24)

< 0.001

1.14(1.05–1.23)

0.001

American Indian/Alaska Native

1.23(1.03–1.46)

0.020

1.28(1.06–1.54)

0.012

Unknown

0.59(0.39–0.88)

0.009

0.60(0.39–0.94)

0.024

Marital Status

Married

Reference

 

Reference

 

Unmarried

1.34(1.28–1.40)

< 0.001

1.31(1.25–1.38)

< 0.001

Unknown

1.23(1.09–1.39)

< 0.001

1.17(1.02–1.34)

0.028

Year of Diagnosis

2004–2007

Reference

 

Reference

 

2008–2011

0.92(0.87–0.97)

0.002

0.94(0.88–1.00)

0.039

2012–2014

0.85(0.79–0.90)

< 0.001

0.85(0.79–0.91)

< 0.001

TNM Stage

I

Reference

 

Reference

 

II

1.17(1.10–1.25)

< 0.001

1.28(1.19–1.38)

< 0.001

III

3.24(3.04–3.45)

< 0.001

3.96(3.70–4.25)

< 0.001

IV

6.11(5.67–6.60)

< 0.001

7.56(6.96–8.22)

< 0.001

Unknown

3.86(3.54–4.20)

< 0.001

4.39(3.99–4.83)

< 0.001

SEER Stage

Localized

Reference

 

Reference

 

Regional

2.25(2.14–2.37)

< 0.001

2.56(2.42–2.71)

< 0.001

Distant

5.30(4.95–5.69)

< 0.001

6.29(5.83–6.78)

< 0.001

Unstaged

3.96(3.41–4.61)

< 0.001

4.06(3.42–4.81)

< 0.001

Pathological Grade

Well differentiated

Reference

 

Reference

 

Moderately differentiated

1.04(0.95–1.14)

0.399

1.09(0.99–1.21)

0.088

Poorly differentiated

1.74(1.56–1.94)

< 0.001

2.00(1.78–2.26)

< 0.001

Undifferentiated

1.65(1.22–2.23)

0.001

1.81(1.30–2.51)

< 0.001

Unknown

1.83(1.70–1.98)

< 0.001

1.91(1.75–2.08)

< 0.001

AFP

Negative

Reference

 

Reference

 

Positive

1.77(1.66–1.88)

< 0.001

1.88(1.76–2.02)

< 0.001

Borderline

1.16(0.74–1.83)

0.513

1.45(0.91–2.31)

0.119

Unknown

1.60(1.48–1.74)

< 0.001

1.64(1.49–1.80)

< 0.001

Tumor Size

<  2 cm

Reference

 

Reference

 

≥ 2 cm

2.20(2.01–2.40)

< 0.001

2.69(2.41–2.99)

< 0.001

Unknown

6.98(6.28–7.75)

< 0.001

8.94(7.90–10.12)

< 0.001

Therapy

None

Reference

 

Reference

 

Tumor Destruction

0.40(0.37–0.43)

< 0.001

0.36(0.33–0.40)

< 0.001

Surgical Resection

0.29(0.27–0.32)

< 0.001

0.28(0.26–0.31)

< 0.001

Liver Transplantation

0.12(0.10–0.13)

< 0.001

0.07(0.06–0.08)

< 0.001

Unknown

1.34(0.91–1.99)

0.140

1.35(0.88–2.07)

0.174

Fibrosis Score

0–4

Reference

 

Reference

 

5–6

1.16(1.10–1.23)

< 0.001

1.11(1.05–1.19)

< 0.001

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