Fig. 2
The schedule of enrolment, interventions and assessments. -t0 during the process of enrolment, t0 baseline, t1 after completion of exercise intervention (equivalent to the end of the patients’ first-line chemotherapy), t2 6 months after completion of exercise intervention, HIIT high-intensity interval endurance training; Placebo control group training (supervised myofascial release training), HVLT-R Hopkins Verbal Learning Test - Revised, COWAT Controlled Oral Word Association Test, TMT Trail Making Test part A/part B, INHIB Response Inhibition Test, FACT-COG Functional Assessment of Cancer Therapy – Cognitive function, TNF-α tumor necrosis factor alpha, IL-6 Interleukin-6, IL-1α Interleukin-1 Alpha, IL-1β Interleukin-1 Beta, CRP C-reactive protein, IL-1RA Interleukin-1 receptor antagonist, IL-10 Interleukin-10, BDNF brain-derived neurotrophic factor, VEGF vascular endothelial growth factor, IGF-1 insulin-like growth factor 1, IXT incremental exercise test, MFI-20 The multidimensional Fatigue Inventory, EORTC-QLQ-C30 core questionnaire 30 items of the European Organization for Research and Treatment of Cancer, HADS-D German version of the Hospital Anxiety and Depression Scale PSQI Pittsburgh Sleeping Quality Index. * As demographic data: age, sex, education, socioeconomic status will be captured. ** As anthropometric data height, weight and BMI will be captured