Table 3 Reasons for treatment with Zarzio®: clinician assessment and Zarzio® treatment in patients given primary vs secondary/curative prophylaxis (analysis population, N = 1174)
Breast (n = 356) | Lung (n = 280) | GI: colorectal (n = 103) | GI: non-colorectal (n = 72) | GYN: ovarian (n = 72) | GYN: non-ovarian (n = 39) | Head & neck (n = 105) | Prostate (n = 66) | Other‡ (n = 81) | Total (N = 1174) | Primary prophylaxis†(n = 772) | Secondary/curative prophylaxis (n = 402) | p value§ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FN risk category according to clinician, n (%) | |||||||||||||
≥ 20% | 133 (37.3) | 92 (32.8) | 24 (23.3) | 24 (33.3) | 27 (37.5) | 14 (35.9) | 49 (46.7) | 29 (43.9) | 43 (53.1) | 435 (37.1) | 321 (41.6) | 114 (28.4) | <0.0001 |
10–20% with risk factors | 174 (48.9) | 162 (57.9) | 60 (58.3) | 39 (54.2) | 43 (59.7) | 23 (59.0) | 45 (42.8) | 32 (48.5) | 34 (42.0) | 612 (52.1) | 389 (50.4) | 223 (55.5) | |
< 10% | 49 (13.8) | 26 (9.3) | 19 (18.4) | 9 (12.5) | 2 (2.8) | 2 (5.1) | 11 (10.5) | 5 (7.6) | 4 (4.9) | 127 (10.8) | 62 (8.0) | 65 (16.2) | |
Reason for G-CSF prescription, n (%)* | |||||||||||||
Elderly patient | 65 (18.3) | 66 (23.6) | 34 (33.0) | 18 (25.0) | 27 (37.5) | 12 (30.8) | 19 (18.1) | 27 (40.9) | 19 (23.5) | 287 (24.4) | 203 (26.3) | 84 (20.9) | 0.04 |
Poor functional or nutritional status | 35 (9.8) | 78 (27.9) | 17 (16.5) | 21 (29.2) | 15 (20.8) | 4 (10.3) | 45 (42.9) | 13 (19.7) | 21 (25.9) | 249 (21.2) | 184 (23.8) | 65 (16.2) | <0.01 |
Low leucocyte levels | 45 (12.6) | 45 (16.1) | 52 (50.5) | 25 (34.7) | 18 (25.0) | 4 (10.3) | 15 (14.3) | 12 (18.2) | 10 (12.3) | 226 (19.3) | 45 (12.6) | 181 (45.0) | <0.0001 |
Concomitant pathologies | 26 (7.3) | 99 (35.4) | 15 (14.6) | 14 (19.4) | 9 (12.5) | 6 (15.4) | 20 (19.0) | 12 (18.2) | 21 (25.9) | 222 (18.9) | 178 (23.1) | 44 (10.9) | <0.0001 |
Low haemoglobin levels | 3 (0.8) | 22 (7.9) | 7 (6.8) | 10 (13.9) | 10 (13.9) | 2 (5.1) | 2 (1.9) | 12 (18.2) | 8 (9.9) | 76 (6.5) | 38 (4.9) | 38 (9.5) | <0.01 |
Prior FN | 19 (5.3) | 13 (4.6) | 3 (2.9) | 4 (5.6) | 9 (12.5) | 0 (0) | 2 (1.9) | 1 (1.5) | 4 (4.9) | 55 (4.7) | 24 (3.1) | 31 (7.7) | <0.001 |
FN in previous CT cycle | 11 (3.1) | 9 (3.2) | 5 (4.9) | 4 (5.6) | 1 (1.4) | 0 (0) | 1 (1.0) | 1 (1.5) | 5 (6.2) | 37 (3.2) | 7 (0.9) | 30 (7.5) | <0.0001 |
Prophylactic antibiotic | 0 (0) | 5 (1.8) | 1 (1.0) | 1 (1.4) | 0 (0) | 0 (0) | 1 (1.0) | 1 (1.5) | 0 (0) | 9 (0.8) | 4 (0.5) | 5 (1.2) | 0.29ǁ |
Other reason** | 219 (61.5) | 106 (37.9) | 31 (30.1) | 23 (31.9) | 31 (43.1) | 20 (51.3) | 40 (38.1) | 33 (50.0) | 37 (45.7) | 540 (46.0) | 391 (50.6) | 149 (37.1) | <0.0001 |